DNA double-strand breaks (DSBs) must be rejoined properly to prevent the occurrence of serious genomic rearrangements associated with many human diseases. Non-homologous end joining (NHEJ) is a DSB repair mechanism known to protect genomic integrity that is also implicated in creating genomic translocations, inversions, deletions, and insertions. We recently investigated the impact of the pre-damage spatial proximity of DSB-bearing loci on the frequency of trans repair by NHEJ and surprisingly found no correlation between them. In this review, we consider various models that might account for these unexpected results. While DSB movement is necessary to explain our findings, many questions remain about the nature and timing of that motion.

中文翻译：

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运动中的双链断裂：对染色体重排的影响。

必须正确地重新连接DNA双链断裂（DSB），以防止发生与许多人类疾病相关的严重基因组重排。非同源末端连接（NHEJ）是一种已知的保护基因组完整性的DSB修复机制，也涉及创建基因组易位，倒位，缺失和插入。我们最近研究了DSB携带基因座的损伤前空间邻近性对NHEJ反式修复频率的影响，令人惊讶地发现它们之间没有相关性。在本文中，我们考虑了可能导致这些意外结果的各种模型。尽管DSB的运动对于解释我们的发现是必要的，但有关该运动的性质和时间安排仍存在许多疑问。