Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. However, the recent impetus to understand the placenta in real time, and the use of functional imaging to comprehend placental biology, warrants a different sampling approach. Here we present a method to standardize placental tissue collection in a format designed to facilitate correlation of in vivo function with ex vivo assessments. Additionally, we draw comparisons to the quadrant biopsy regimen, and highlight a pathological case of placental infarction detected by in utero imaging.

中文翻译：

---

在功能磁共振成像时代收集人胎盘样品的标准化方法。

当前用于胎盘组织收集的方法评估了没有直接功能相关性的被递送器官。因此，许多研究人员采用的四象限活检方案可能提供跨大器官组织的合理表示，并为胎盘的分子分析提供快照。然而，最近对实时了解胎盘的推动力以及使用功能成像来理解胎盘生物学的保证了另一种采样方法。在这里，我们提出了一种标准化胎盘组织收集的方法，该格式旨在促进体内功能与离体评估的相关性。此外，我们对象限活检方案进行了比较，并强调了由在子宫内成像。