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Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929867326666190712154021
Fei Peng 1 , Wensheng Zhang 1 , Feng Qiu 1
Affiliation  

Background: The development of modern nanomedicine greatly depends on the involvement of novel materials as drug delivery system. In order to maximize the therapeutic effects of drugs and minimize their side effects, a number of natural or synthetic materials have been widely investigated for drug delivery. Among these materials, biomimetic self-assembling peptides (SAPs) have received more attention in recent years. Considering the rapidly growing number of SAPs designed for drug delivery, a summary of how SAPs-based drug delivery systems were designed, would be beneficial.

Method: We outlined research works on different SAPs that have been investigated as carriers for different drugs, focusing on the design of SAPs nanomaterials and how they were used for drug delivery in different strategies.

Results: Based on the principle rules of chemical complementarity and structural compatibility, SAPs such as ionic self-complementary peptide, peptide amphiphile and surfactant-like peptide could be designed. Determined by the features of peptide materials and the drugs to be delivered, different strategies such as hydrogel embedding, hydrophobic interaction, electrostatic interaction, covalent conjugation or the combination of them could be employed to fabricate SAPs-drug complex, which could achieve slow release, targeted or environment-responsive delivery of drugs. Furthermore, some SAPs could also be combined with other types of materials for drug delivery, or even act as drug by themselves.

Conclusion: Various types of SAPs have been designed and used for drug delivery following various strategies, suggesting that SAPs as a category of versatile nanomaterials have promising potential in the field of nanomedicine.



中文翻译:

当前纳米医学中的自组装肽:用于药物递送的多功能纳米材料。

背景:现代纳米医学的发展很大程度上取决于新型材料作为药物输送系统的参与。为了最大化药物的治疗效果并最小化其副作用,已经广泛研究了许多天然或合成材料用于药物递送。在这些材料中,仿生自组装肽(SAP)近年来受到越来越多的关注。考虑到为药物递送设计的SAP数量迅速增长,对基于SAP的药物递送系统的设计方式进行总结将是有益的。

方法:我们概述了已作为不同药物的载体进行研究的不同SAP的研究工作,重点是SAP纳米材料的设计以及它们在不同策略中如何用于药物递送。

结果:根据化学互补性和结构相容性的基本规律,可以设计离子自互补肽,肽两亲性和表面活性剂样肽等SAP。根据肽材料和所递送药物的特性,可以采用不同的策略(例如水凝胶包埋,疏水相互作用,静电相互作用,共价结合或它们的组合)来制备SAPs-药物复合物,从而实现缓慢释放,有针对性或对环境敏感的药物交付。此外,某些SAP也可以与其他类型的材料组合用于药物输送,甚至可以自己充当药物。

结论:已经按照各种策略设计了各种类型的SAP并将其用于药物输送,这表明SAP作为一类通用的纳米材料在纳米医学领域具有广阔的发展潜力。

更新日期:2020-09-02
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