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Understanding the Physiology of Liberibacter asiaticus: An Overview of the Demonstrated Molecular Mechanisms.
Microbial Physiology ( IF 1.2 ) Pub Date : 2018-09-04 , DOI: 10.1159/000492386
Janelle F Coyle , Graciela L Lorca , Claudio F Gonzalez

Citrus greening disease, or huanglongbing, may entirely eradicate all varieties of citrus cultivars worldwide in the near future. This disease is caused by non-cultivable bacteria of the genus Liberibacter; among them, the more pathogenic being Liberibacter asiaticus. The complexity of the host-pathogen relationship, associated with the impossibility of performing research using axenic cultures, has severely hindered the basic research on microbiology. Since its genome sequence was published in 2009, most of the scientific publications in the field were dedicated to in silico analysis and selection of targets to design early detection methods. The knowledge gained with these approaches felt short to articulate effective methods to control the disease progression. There is a critical need to understand the basic biology of bacteria to design effective strategies to inactivate central mechanisms of pathogenesis. In this review, we summarize the scientific progress made by studying L. asiaticus' biology through direct experimentation. The evidence collected thus far is not enough to understand L. -asiaticus' fundamental biology. It is imperiously necessary to increase the basic research to identify relevant biological clues to control citrus greening. The gained knowledge may also help to prevent potential catastrophic diseases in other crops of significant importance caused by other unculturable Liberibacter species.

中文翻译:

了解Liberibacter asiaticus的生理学:展示的分子机制概述。

在不久的将来,柑橘绿化病或黄龙病可能会彻底根除全世界所有柑橘品种。这种疾病是由利比里亚细菌的不可培养细菌引起的。其中,致病性更强的是亚洲自由杆菌。宿主与病原体之间关系的复杂性,以及无法使用树莓培养物进行研究,严重地阻碍了微生物学的基础研究。自从其基因组序列于2009年发表以来,该领域的大多数科学出版物都致力于计算机分析和目标选择,以设计早期检测方法。通过这些方法获得的知识不足以阐明有效的方法来控制疾病的进展。迫切需要了解细菌的基本生物学,以设计有效的策略来灭活发病机理的中心机制。在这篇综述中,我们总结了通过直接实验研究亚洲乳杆菌生物学的科学进展。迄今为止收集的证据不足以了解亚述乳杆菌的基本生物学。迫切需要增加基础研究,以发现相关的生物学线索来控制柑橘的绿化。所获得的知识还可能有助于预防其他不可培养的利比里亚细菌物种在其他重要作物中造成潜在的灾难性疾病。通过直接实验进行生物学。迄今为止收集的证据不足以了解亚述乳杆菌的基本生物学。迫切需要增加基础研究,以发现相关的生物学线索来控制柑橘的绿化。所获得的知识还可能有助于预防其他不可培养的利比里亚细菌物种在其他重要作物中造成潜在的灾难性疾病。通过直接实验进行生物学。迄今为止收集的证据不足以了解亚述乳杆菌的基本生物学。迫切需要增加基础研究,以发现相关的生物学线索来控制柑橘的绿化。所获得的知识还可能有助于预防其他不可培养的利比里亚细菌物种在其他重要作物中造成潜在的灾难性疾病。
更新日期:2019-11-01
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