Acute pancreatitis (AP) is a digestive disease characterized by pancreatic inflammation. Tetramethylpyrazine (TMP) has been effectively used to ameliorate the damage on intestinal mucosa injury in rats with acute necrotizing pancreatitis (ANP). We aim to study the protective effect of TMP on caerulein-induced AP and to explore the possible mechanism. The mice randomized into control and different experimental groups. AP was induced in mice by 6-hourly intraperitoneal (i.p) injections of caerulein (50 μg/kg at 1 h interval). TMP (i.p, 10 mg/kg, 1 h interval) was administered 3 h before caerulein injection. Administration of TMP attenuated the severity of AP as shown by the histopathology, reduced serum amylase activity and pro-inflammatory cytokines TNF-α and IL-6. Further, TMP enhances the beneficial effect by reducing caerulein-induced NF-κB activation and inducing cell apoptosis in pancreas. Therefore, inhibition of nuclear factor-kappa B(NF-κB) signals by TMP represents a potential therapeutic strategy for the treatment of acute pancreatitis.

急性胰腺炎（AP）是一种以胰腺炎症为特征的消化系统疾病。四甲基吡嗪（TMP）已被有效地用于减轻急性坏死性胰腺炎（ANP）大鼠肠道粘膜损伤。我们旨在研究TMP对油青素诱导的AP的保护作用，并探讨其可能的机制。小鼠随机分为对照组和不同的实验组。通过6小时一次的腹膜内（ip）注射caerulein（50μg/ kg间隔1 h）诱导小鼠AP。在注射caerulein前3 h给予TMP（ip，10 mg / kg，间隔1 h）。如组织病理学所示，TMP的给药可减轻AP的严重程度，降低血清淀粉酶活性以及促炎性细胞因子TNF-α和IL-6。此外，TMP通过减少菜青素诱导的NF-κB活化并诱导胰腺细胞凋亡来增强有益作用。因此，