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Do serum androgens influence blastocysts ploidy in karyotypically normal women?
Systems Biology in Reproductive Medicine ( IF 2.4 ) Pub Date : 2019-04-17 , DOI: 10.1080/19396368.2019.1601295
Michał Kunicki 1, 2 , Patrycja Skowrońska 3 , Ewa Pastuszek 3, 4 , Grzegorz Jakiel 1, 5 , Roman Smolarczyk 2 , Krzysztof Łukaszuk 1, 2, 3, 4
Affiliation  

The aim of the study was to determine if serum testosterone (T) and dehydroepiandrosterone (DHEAS) levels are a factor in determining increased risk for embryonic aneuploidy in karyotypically normal women undergoing in vitro fertilization (IVF) and preimplantation genetic testing screening for aneuploidy (PGT-A). This is a retrospective cohort study of IVF cycles with PGT-A performed during 2015–2016. A total of 256 cycles with 725 embryos were initially considered for inclusion. A total of 208 cycles and 595 embryos determined to be either euploid or aneuploid were included in the analysis. The mean age of women was 37.4 ± 4.4 years. There were 193 (32.44%) euploid, and 338 (56.81%) aneuploid blastocysts. Sixty-four (10.76%) had ‘no diagnosis’ after PGT-A. The 32 embryos with ‘no diagnosis’ after first PGT-A were biopsied again and after the second analysis, 7 were found to be euploid and 3 aneuploid. The remaining 32 embryos were not reanalyzed due to the lack of patients’ consent for the second biopsy. The relationship between embryo ploidy and levels of serum testosterone and dehydroepiandrosterone sulfate was assessed using ordinal multivariable regression analysis. The model, adjusted for both anti-Mullerian hormone (AMH) and age, showed no association between ploidy status and serum levels of the two hormones. We concluded that the serum levels of testosterone and DHEAS do not influence embryo ploidy in karyotypically normal women undergoing IVF.

Abbreviations: T: testosterone; DHEAS: dehydroepiandrosterone; IVF: in vitro fertilization; PGT-A: preimplantation genetic testing screening for aneuploidy; AMH: anti-Mullerian hormone; FSH: follicle-stimulating hormone; LH: luteinizing hormone; E2: oestradiol; P: progesterone



中文翻译:

血清雄激素是否会影响核型正常女性的胚泡倍性?

该研究的目的是确定是否有血清睾丸激素(T)和脱氢表雄酮(DHEAS)水平是确定 体外进行核型分析的正常女性中胚胎非整倍性风险增加的因素受精(IVF)和非整倍性的植入前基因测试筛选(PGT-A)。这是一项在2015–2016年期间进行的IVF周期与PGT-A的回顾性队列研究。最初考虑包括725个胚胎的总共256个周期。分析中总共确定了208个周期和595个胚胎为整倍体或非整倍体。妇女的平均年龄为37.4±4.4岁。有193个(32.44%)整倍体和338个(56.81%)非整倍体胚泡。在PGT-A治疗后有64名(10.76%)没有“诊断”。再次活检首次PGT-A后32个“无诊断”的胚胎,第二次分析后,发现7个为整倍体和3个为非整倍体。由于缺乏患者第二次活检的同意,其余的32个胚胎没有重新分析。使用有序多变量回归分析评估了胚胎倍性与血清睾丸激素和硫酸脱氢表雄酮水平之间的关系。针对抗穆勒氏激素(AMH)和年龄进行调整的模型显示,倍性状态与两种激素的血清水平之间没有关联。我们得出的结论是,在接受IVF的核型正常妇女中,睾丸激素和DHEAS的血清水平不会影响胚胎倍性。

缩写:T:睾丸激素;DHEAS:脱氢表雄酮;试管婴儿: 试管受精; PGT-A:植入前基因测试的非整倍性筛选;AMH:抗穆勒激素;FSH:促卵泡激素;LH:促黄体激素;E 2:雌二醇;P:黄体酮

更新日期:2019-04-17
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