Background: Ovarian cancer is a heterogeneous disease, where chronic inflammation is one of the central mechanisms of its pathogenesis. The objectives of the study were to evaluate the expression of CD3, CD4, CD8 and CD20 in the peritumoral stroma of benign and malignant ovarian epithelial neoplasms and to relate them to prognostic factors in ovarian cancer. Methods: We evaluated 77 patients (40 benign epithelial ovarian neoplasms and 37 malignant epithelial ovarian neoplasms). Immunohistochemistry study for cytokines (CD3, CD4, CD8 and CD20) was performed. The evaluation of prognostic factors was performed using the Fisher's exact test. The significance level was less than 0.05. Results: A higher CD3 expression was found in the stroma of ovarian malignancies compared benign neoplasms, and greater expression of CD4 cells in the stroma of benign neoplasms compared to ovarian cancer. There was a greater expression of CD8 cells in the stromal ovarian malignancies with molecular type II compared to type I. In the evaluation of lymph node metastases, the absence of immuno-labelling of CD20 cells was associated with the absence of lymph node metastases. Conclusion: The immune system plays a multifaceted role and can promote or inhibit tumor growth in different contexts.

中文翻译：

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腹膜间质中的淋巴细胞：卵巢上皮肿瘤中的评估。

背景：卵巢癌是一种异质性疾病，其中慢性炎症是其发病机理的主要机制之一。这项研究的目的是评估CD3，CD4，CD8和CD20在良性和恶性卵巢上皮肿瘤的肿瘤周围基质中的表达，并将其与卵巢癌的预后因素相关联。方法：我们评估了77例患者（40例良性上皮性卵巢肿瘤和37例恶性上皮性卵巢肿瘤）。进行了细胞因子（CD3，CD4，CD8和CD20）的免疫组织化学研究。使用Fisher精确检验对预后因素进行评估。显着性水平小于0.05。结果：与良性肿瘤相比，卵巢恶性肿瘤的基质中CD3表达更高，与卵巢癌相比，良性肿瘤基质中CD4细胞的表达更高。与I型分子相比，II型分子的间质性卵巢癌中CD8细胞的表达更高。在评估淋巴结转移时，CD20细胞缺乏免疫标记与淋巴结转移无关。结论：免疫系统具有多种作用，可以在不同情况下促进或抑制肿瘤的生长。