Rod-shape nanoplatform have received tremendous attention owing to their enhanced ability for cell internalization and high capacity for drug loading. MoS2, widely used in electronic devices, electrocatalysis, sensor and energy-storage, has been studied as photothermal agents over the years. However, the efficacy of rod-shape MoS2 based photothermal agents for photothermal therapy has not been studied before. Here, a near-infrared (NIR) light-absorbing MoS2 nanosheets coated mesoporous silica nanorods with human serum albumin (HSA) modifying and Ce6 loading (MSNR@MoS2-HSA/Ce6) were constructed for combined photothermal and photodynamic therapy. Methods: The near-infrared (NIR) light was used to trigger the synergistic anti-tumor therapy. In addition, breast cancer cell line was applied to evaluate the in vitro anti-tumor activity. The multi-modal imaging capacity and tumor-killing efficiency of the designed nanocomposites in vivo was also demonstrated with the 4T1 tumor-bearing mouse model. Results: These nanocomposites could not only perform NIR light triggered photodynamic therapy (PDT) and photothermal therapy (PTT), but also achieve in vivo fluorescence (FL) /multispectral optical tomography (MSOT)/X-ray computed tomography (CT) triple-model bioimaging. What's more, the rod-shape nanoplatform could be endowed with better anti-tumor ability based on the EPR effect and HSA-mediated active tumor targeting. At the same time, the hyperthermia generated by MoS2 could synergistically improve the PDT effect with the acceleration of the blood flow, leading to the increase of the oxygen level in tumor tissue. Conclusion: MSNR@MoS2-HSA/Ce6 proves to be a promising multi-functional nanoplatform for effective treatment of tumor.

中文翻译：

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棒状MSN @ MoS2纳米平台，用于FL / MSOT / CT成像引导的光热和光动力疗法。

棒状纳米平台由于其增强的细胞内在化能力和高载药量而受到广泛关注。多年来，MoS2广泛用于电子设备，电催化，传感器和能量存储中，并已作为光热剂进行了研究。但是，以前没有研究过基于棒状MoS2的光热剂对光热疗法的功效。在这里，构建了具有人血清白蛋白（HSA）修饰和Ce6负载（MSNR @ MoS2-HSA / Ce6）的中孔二氧化硅纳米棒包覆的近红外（NIR）光吸收MoS2纳米片，用于光热和光动力疗法的组合。方法：使用近红外（NIR）光触发协同抗肿瘤治疗。另外，将乳腺癌细胞系应用于评估体外抗肿瘤活性。还用4T1荷瘤小鼠模型证明了设计的纳米复合材料在体内的多模式成像能力和肿瘤杀灭效率。结果：这些纳米复合材料不仅可以执行近红外光触发光动力疗法（PDT）和光热疗法（PTT），而且还可以实现体内荧光（FL）/多光谱光学层析成像（MSOT）/ X射线计算机层析成像（CT）三重-模型生物成像。此外，基于EPR效应和HSA介导的主动肿瘤靶向，棒状纳米平台可具有更好的抗肿瘤能力。同时，MoS2产生的高温可以随着血流的加速协同改善PDT的作用，从而导致肿瘤组织中的氧水平升高。结论：