Chikungunya virus (CHIKV), a highly contagious re-emerging virus, is transmitted by infected mosquitoes. CHIKV is prevalent in tropical countries and is continuing to creep farther north into temperate areas. CHIKV is responsible for induction of chikungunya fever (CF) and severe joint stiffness with the capability of developing into bilateral and systemic arthralgia or even encephalitis. Despite the high morbidity rate, no approved antiviral drug is available. Therefore, an anti-CHIKV therapy is necessary to control this disease. In this study, we screened four flavonoids for anti-CHIKV activities: nobiletin, phlorizin, resveratrol and oxyresveratrol.

中文翻译：

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诺比列汀对基孔肯雅病毒的体外抗病毒活性。

基孔肯雅热病毒（CHIKV）是一种具有高度传染性的再生病毒，是由受感染的蚊子传播的。CHIKV在热带国家盛行，并继续向北蔓延至温带地区。CHIKV负责诱发基孔肯雅热（CF）和严重的关节僵硬，并有发展为双侧和全身性关节痛甚至脑炎的能力。尽管发病率很高，但没有批准的抗病毒药物可供使用。因此，抗CHIKV疗法对于控制该疾病是必要的。在这项研究中，我们针对抗Chikv活性筛选了四个类黄酮：诺比列汀，phlorizin，白藜芦醇和氧白藜芦醇。