Little is known about early coincidental changes in bone and vascular properties, particularly in the context of skeletal anabolism (puberty) versus relative equilibrium (young adulthood). We aimed to determine if subclinical markers of vascular function were associated with bone mineral content (BMC) and to evaluate the contribution of systemic factors in healthy females ages 14-42 years. Endothelial function was assessed by flow mediated dilatation (FMD), arterial stiffness by pulse wave velocity (PWV) and augmentation index (AIx), blood pressure (BP) by sphygmomanometer, BMC by DXA, and systemic factors by fasting blood draw. General linear models controlled for age, race and height indicated a positive association between systolic BP (SBP) and BMC independent of systemic factors. When stratified by age using 19 years as a cut-point, there was an inverse relationship between AIx75 in adolescents with insulin (P<0.10) or inflammatory markers (P<0.10) in statistical models. Conversely, there was a positive relationship between BMC and both PWV and AIx75 in young adults (P<0.05). The link between bone and the vasculature may be life stage-dependent. In the context of a less dynamic microenvironment in young adult females, metabolic factors appear to moderate less of an effect of hemodynamic properties on the skeleton relative to adolescents.

中文翻译：

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骨骼和心血管特性标记之间的关联的亚临床指征。

人们对骨骼和血管特性的早期同时发生变化知之甚少，尤其是在骨骼合成代谢（青春期）与相对平衡（成年后）的背景下。我们旨在确定血管功能的亚临床标志物是否与骨矿物质含量（BMC）相关，并评估全身因素在14-42岁健康女性中的作用。通过血流介导的扩张（FMD），通过脉搏波速度（PWV）和增强指数（AIx）评估动脉僵硬度，通过血压计评估血压（BP），通过DXA评估BMC以及通过禁食抽血评估全身性因素来评估内皮功能。受年龄，种族和身高控制的通用线性模型表明，收缩压（SBP）与BMC之间呈正相关，而与系统性因素无关。以19岁为切入点按年龄分层时，在统计模型中，有胰岛素（P <0.10）的青少年AIx75与炎性标志物（P <0.10）呈负相关。相反，年轻人中BMC与PWV和AIx75均呈正相关（P <0.05）。骨骼和脉管系统之间的联系可能取决于生命阶段。在年轻成年女性的微环境动态性较低的情况下，相对于青少年，代谢因子似乎对骨骼的血液动力学性质的影响较小。