The literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting in a number of known biological and metabolic roles. This review is focused on the roles played by PARP enzymes in host-pathogen interactions and in diseases with an associated inflammatory response. In mammalian cells, several PARPs have specific roles in the antiviral response; this is perhaps best illustrated by PARP13, also termed the zinc finger antiviral protein (ZAP). Plant stress responses and immunity are also regulated by poly(ADP-ribosyl)ation. PARPs promote inflammatory responses by stimulating proinflammatory signal transduction pathways that lead to the expression of cytokines and cell adhesion molecules. Hence, PARP inhibitors show promise in the treatment of inflammatory disorders and conditions with an inflammatory component, such as diabetes, arthritis, and stroke. These functions are correlated with the biophysical characteristics of PARP family enzymes. This work is important in providing a comprehensive understanding of the molecular basis of pathogenesis and host responses, as well as in the identification of inhibitors. This is important because the identification of inhibitors has been shown to be effective in arresting the progression of disease.

中文翻译：

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宿主病原菌相互作用，炎症和免疫中的聚（ADP-核糖）聚合酶。

此处提供的文献综述详细介绍了涉及蛋白质的聚（ADP-核糖）聚合酶（PARP）家族成员的最新研究。在家族的17个公认成员中，人类酶PARP1的研究最为广泛，从而导致了许多已知的生物学和代谢作用。这篇综述着重于PARP酶在宿主-病原体相互作用以及具有相关炎症反应的疾病中的作用。在哺乳动物细胞中，几种PARPs在抗病毒反应中具有特定作用。这也许可以通过PARP13（也称为锌指抗病毒蛋白（ZAP））得到最好的说明。聚（ADP-核糖基）化也调节植物的胁迫反应和免疫力。PARPs通过刺激促炎信号转导途径促进发炎反应，促炎信号转导途径导致细胞因子和细胞粘附分子的表达。因此，PARP抑制剂在治疗炎性疾病和炎性成分例如糖尿病，关节炎和中风方面表现出希望。这些功能与PARP家族酶的生物物理特性相关。这项工作对于全面了解发病机理和宿主反应的分子基础以及鉴定抑制剂非常重要。这很重要，因为已证明抑制剂的识别可有效阻止疾病的进展。PARP抑制剂在治疗炎症性疾病和炎症性疾病（如糖尿病，关节炎和中风）方面显示出希望。这些功能与PARP家族酶的生物物理特性相关。这项工作对于全面了解发病机理和宿主反应的分子基础以及鉴定抑制剂非常重要。这很重要，因为已证明抑制剂的识别可有效阻止疾病的进展。PARP抑制剂在治疗炎症性疾病和炎症性疾病（如糖尿病，关节炎和中风）方面显示出希望。这些功能与PARP家族酶的生物物理特性相关。这项工作对于全面了解发病机理和宿主反应的分子基础以及鉴定抑制剂非常重要。这很重要，因为已证明抑制剂的识别可有效阻止疾病的进展。以及抑制剂的鉴定。这很重要，因为已证明抑制剂的识别可有效阻止疾病的进展。以及抑制剂的鉴定。这很重要，因为已证明抑制剂的识别可有效阻止疾病的进展。