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Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection.
Journal of Innate Immunity ( IF 5.3 ) Pub Date : 2019-07-03 , DOI: 10.1159/000500545
Bryan van den Broek 1, 2, 3 , Michiel van der Flier 1, 2, 3, 4 , Ronald de Groot 2, 3 , Marien I de Jonge 2, 3 , Jeroen D Langereis 5, 6
Affiliation  

Streptococcus pneumoniae and Neisseria meningitidis are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including S. pneumoniae and N. meningitidis. While it is widely accepted that complement deficiencies due to rare genetic variants increase the risk for invasive bacterial infection, not much is known about the common genetic variants in the complement system in relation to disease susceptibility. In this review, we provide an overview of the effects of common genetic variants on complement activation and on complement-mediated inflammation.

中文翻译:

补体系统中的常见遗传变异及其与疾病易感性和侵袭性细菌感染结果的潜在联系。

肺炎链球菌和脑膜炎奈瑟菌是经常以无症状方式定植于鼻咽部的病原体,但也是主要发生在幼儿中的侵袭性细菌感染的原因。补体系统在体液免疫中起着至关重要的作用,补充抗体清除微生物的能力,从而保护宿主免受细菌感染,包括肺炎链球菌和脑膜炎奈瑟菌。虽然人们普遍认为,由于罕见遗传变异导致的补体缺乏会增加侵袭性细菌感染的风险,但对补体系统中与疾病易感性相关的常见遗传变异知之甚少。在这篇综述中,我们概述了常见遗传变异对补体激活和补体介导的炎症的影响。
更新日期:2019-11-01
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