OBJECTIVES Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD). METHODS Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD. RESULTS Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; P < .0001). Over time, apathy became more frequent in AD with increasing dementia severity (33%-41%; P < .006). CONCLUSIONS Alzheimer disease neuropathology had the closest association with the neuropsychiatric symptom of apathy, while FTLD was most associated with the combination of apathy and disinhibition. Over time, the frequency of those with apathy increased in both AD and FTLD neuropathology.

中文翻译：

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与失忆症和行为痴呆症的神经病理学相关的冷漠和抑制。

目的研究临床诊断为阿尔茨海默氏型痴呆（DAT）或行为变异额颞叶痴呆（bvFTD），神经病理学为阿尔茨海默病（AD）或额颞叶变性（FTLD）的患者的无知和抑制作用的频率。方法回顾性分析887例患者的回顾性数据，比较DAT / AD，DAT / FTLD，bvFTD / FTLD和bvFTD / AD 4组在基线和纵向的冷漠和去抑制的频率。结果单独的冷漠在AD（33％）中比FTLD（25％）更普遍，而FTLD（43％）的冷漠与去抑制相结合在AD（14％; P <.0001）中更为普遍。随着时间的流逝，痴呆症的严重程度增加，AD的冷漠变得更加频繁（33％-41％； P <.006）。结论阿尔茨海默氏病的神经病理学与冷漠的神经精神症状最密切相关，而FTLD与冷漠和解除抑制的组合最密切相关。随着时间的流逝，AD和FTLD神经病理学中出现冷漠的人的频率增加。