Cerebrovascular disease (CVD) contributes to spatial navigation deficits; however, the everyday outcomes of this association remain unexplored. We investigated whether CVD was a risk for getting lost behavior (GLB) in elderly with mild cognitive impairment (MCI) and mild Alzheimer disease (AD). Getting lost behavior was assessed using a semistructured clinical interview and was associated with white matter lesions (WMLs) in patients with MCI. Specifically, right occipital WMLs increased the odds of GLB by 12 times (P = .03) and right temporal WMLs increased the odds of GLB by 4 times (P = .01), regardless of age, gender, global cognitive impairment, and occipital or medial temporal gray matter atrophy. Hypertension increased the risk of GLB in MCI by contributing to the burden of WMLs. White matter lesions were not associated with GLB in mild AD. Our findings suggest that interventions aimed at reducing GLB in prodromal dementia may involve preventing WMLs by optimizing hypertension control.

中文翻译：

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脑血管疾病是前驱性痴呆行为丧失的风险。

脑血管疾病（CVD）会导致空间导航功能障碍；但是，这种关联的日常结果仍待探索。我们调查了患有轻度认知障碍（MCI）和轻度阿尔茨海默病（AD）的老年人，CVD是否存在迷失行为（GLB）的风险。通过半结构化临床访谈评估迷失行为，并与MCI患者的白质病变（WML）相关。具体而言，无论年龄，性别，整体认知障碍和枕骨如何，右枕WML使GLB的几率增加12倍（P = .03），右颞WML使GLB的几率增加4倍（P = .01）。或颞中部灰质萎缩。高血压通过增加WML负担增加了MCI中GLB的风险。在轻度AD中，白质病变与GLB无关。