Prion ( IF 2.3 ) Pub Date : 2019-03-19 , DOI: 10.1080/19336896.2019.1583042 William L Miller 1 , W David Walter 2
Genetic variability in the prion protein (Prnp) gene influences host susceptibility to many pathogenic prion diseases. Understanding the distribution of susceptible Prnp variants and determining factors influencing spatial genetic patterns are important components of many chronic wasting disease mitigation strategies. Here, we describe Prnp variability in white-tailed deer (Odocoileus virginianus) from the Mid-Atlantic region of the United States of America, an area with a recent history of infection and low disease incidence. This population is characterized by lower rates of polymorphism and significantly higher frequencies of the more susceptible 96GG genotype compared to previously surveyed populations. The prevalence of the most susceptible genotypes at disease-associated loci did vary among subregions, indicating that populations have innate differences in genotype-dictated susceptibility.
中文翻译:
recently病毒基因多态性在最近被慢性消耗性疾病感染的区域中的空间异质性。
ion病毒蛋白(Prnp)基因的遗传变异性影响宿主对许多病原性病毒疾病的敏感性。了解易感Prnp变体的分布并确定影响空间遗传模式的因素是许多慢性消耗性疾病缓解策略的重要组成部分。在这里,我们描述了白尾鹿(Odocoileus virginianus)的Prnp变异性。)来自美利坚合众国中大西洋地区,该地区最近有感染史,且发病率低。与先前调查的人群相比,该人群的特征在于较低的多态性比率和更易感染的96GG基因型的频率明显更高。在疾病相关位点,最易感基因型的患病率在各个亚区域之间确实存在差异,这表明人群在基因型决定的易感性方面存在先天差异。