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DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.
Physiological Reviews ( IF 33.6 ) Pub Date : 2018-06-14 , DOI: 10.1152/physrev.00064.2017 Alexandre Caron 1 , David M Briscoe 1 , Denis Richard 1 , Mathieu Laplante 1
Physiological Reviews ( IF 33.6 ) Pub Date : 2018-06-14 , DOI: 10.1152/physrev.00064.2017 Alexandre Caron 1 , David M Briscoe 1 , Denis Richard 1 , Mathieu Laplante 1
Affiliation
DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a kinase at the center of two important protein complexes named mTORC1 and mTORC2. These highly studied complexes play essential roles in regulating growth, metabolism, and immunity in response to mitogens, nutrients, and cytokines. Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches aiming at modulating mTOR activity are envisioned as an attractive strategy to improve human health. DEPTOR interaction with mTOR represses its kinase activity and rewires the mTOR signaling pathway. Over the last years, several studies have revealed key roles for DEPTOR in numerous biological and pathological processes. Here, we provide the current state of the knowledge regarding the cellular and physiological functions of DEPTOR by focusing on its impact on the mTOR pathway and its role in promoting health and disease.
中文翻译:
癌症,新陈代谢和免疫力的结合者。
包含DEP域的雷帕霉素(mTOR)相互作用蛋白(DEPTOR)的机制靶标是mTOR的重要调节剂,mTOR是位于两个重要的蛋白复合体mTORC1和mTORC2中心的激酶。这些经过高度研究的复合物在调节生长,代谢和对有丝分裂原,营养素和细胞因子的免疫力方面起着至关重要的作用。mTOR信号转导的缺陷与许多疾病的发展有关,包括癌症和糖尿病,并且旨在调节mTOR活性的方法被认为是改善人类健康的有吸引力的策略。DEPTOR与mTOR的相互作用会抑制其激酶活性并重新连接mTOR信号通路。在过去的几年中,多项研究揭示了DEPTOR在众多生物学和病理学过程中的关键作用。这里,
更新日期:2019-11-01
中文翻译:
癌症,新陈代谢和免疫力的结合者。
包含DEP域的雷帕霉素(mTOR)相互作用蛋白(DEPTOR)的机制靶标是mTOR的重要调节剂,mTOR是位于两个重要的蛋白复合体mTORC1和mTORC2中心的激酶。这些经过高度研究的复合物在调节生长,代谢和对有丝分裂原,营养素和细胞因子的免疫力方面起着至关重要的作用。mTOR信号转导的缺陷与许多疾病的发展有关,包括癌症和糖尿病,并且旨在调节mTOR活性的方法被认为是改善人类健康的有吸引力的策略。DEPTOR与mTOR的相互作用会抑制其激酶活性并重新连接mTOR信号通路。在过去的几年中,多项研究揭示了DEPTOR在众多生物学和病理学过程中的关键作用。这里,