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Secondary Metabolites from Deep-sea Derived Microorganisms.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-10-31 , DOI: 10.2174/0929867326666190618153950
Chunxiao Sun 1 , Shah Mudassir 1 , Zhenzhen Zhang 1 , Yanyan Feng 1 , Yimin Chang 1 , Qian Che 1 , Qianqun Gu 1 , Tianjiao Zhu 1 , Guojian Zhang 1 , Dehai Li 1, 2
Affiliation  

Microorganisms obtained from the deep sea are a rich source of marine natural products with distinctive chemical structures and bioactivities. In this review, we will provide a retrospective of outstanding research within the scope of deep-sea (≥1000 m) microbial natural products, which has produced up to 442 compounds by the end of 2017. Approximetely, 60% of these structures have demonstrated various biological activities with more than 30% showing cytotoxic function. In this review, we particularly summarize those successful research on secondary metabolites produced by deep-sea derived microorganisms with inclusion of structural characteristics, biological activities, together with biogenetic origins and taxonomic features of the source microorganisms, from which, we expect to provide more comprehensive understanding of small molecules obtained from deep-sea environment and benefit the ongoing scholarly endeavors in the search for novel pharmaceutical agents from the deep-sea derived microorganisms.



中文翻译:

来自深海微生物的次生代谢产物。

从深海获得的微生物是海洋天然产物的丰富来源,具有独特的化学结构和生物活性。在这篇综述中,我们将对深海(≥1000 m)微生物天然产物范围内的杰出研究进行回顾,该产物到2017年底已生产了442种化合物。大约有60%的结构已经证明超过30%的多种生物活性表现出细胞毒性功能。在这篇综述中,我们特别总结了对深海衍生微生物产生的次生代谢产物的成功研究,这些代谢产物包括结构特征,生物学活性以及源微生物的生物遗传起源和分类学特征,

更新日期:2020-11-05
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