当前位置: X-MOL 学术Curr. Genomics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
An Overview About the Biology of Skeletal Muscle Satellite Cells
Current Genomics ( IF 2.6 ) Pub Date : 2019-02-27 , DOI: 10.2174/1389202920666190116094736
Laura Forcina 1 , Carmen Miano 1 , Laura Pelosi 1 , Antonio Musarò 1
Affiliation  

The peculiar ability of skeletal muscle tissue to operate adaptive changes during post-natal de-velopment and adulthood has been associated with the existence of adult somatic stem cells. Satellite cells, occupying an exclusive niche within the adult muscle tissue, are considered bona fide stem cells with both stem-like properties and myogenic activities. Indeed, satellite cells retain the capability to both maintain the quiescence in uninjured muscles and to be promptly activated in response to growth or re-generative signals, re-engaging the cell cycle. Activated cells can undergo myogenic differentiation or self-renewal moving back to the quiescent state. Satellite cells behavior and their fate decision are finely controlled by mechanisms involving both cell-autonomous and external stimuli. Alterations in these regu-latory networks profoundly affect muscle homeostasis and the dynamic response to tissue damage, con-tributing to the decline of skeletal muscle that occurs under physio-pathologic conditions. Although the clear myogenic activity of satellite cells has been described and their pivotal role in muscle growth and regeneration has been reported, a comprehensive picture of inter-related mechanisms guiding muscle stem cell activity has still to be defined. Here, we reviewed the main regulatory networks determining satellite cell behavior. In particular, we focused on genetic and epigenetic mechanisms underlining satel-lite cell maintenance and commitment. Besides intrinsic regulations, we reported current evidences about the influence of environmental stimuli, derived from other cell populations within muscle tissue, on satel-lite cell biology.

中文翻译:

骨骼肌卫星细胞生物学概述

骨骼肌组织在出生后发育和成年期间操作适应性变化的特殊能力与成人体干细胞的存在有关。卫星细胞在成人肌肉组织中占据独特的位置,被认为是具有干细胞样特性和生肌活性的真正干细胞。事实上,卫星细胞既能维持未受伤肌肉的静止状态,又能响应生长或再生信号迅速激活,重新参与细胞周期。活化的细胞可以经历生肌分化或自我更新,回到静止状态。卫星细胞的行为及其命运决定受到涉及细胞自主和外部刺激的机制的精细控制。这些调节网络的改变深刻地影响肌肉稳态和对组织损伤的动态反应,导致在生理病理条件下发生的骨骼肌衰退。尽管已经描述了卫星细胞的明确的生肌活性,并且已经报道了它们在肌肉生长和再生中的关键作用,但仍然需要定义指导肌肉干细胞活动的相互关联机制的全面图景。在这里,我们回顾了决定卫星小区行为的主要监管网络。特别是,我们专注于强调卫星细胞维护和承诺的遗传和表观遗传机制。除了内在规则外,我们还报告了有关环境刺激影响的最新证据,这些刺激来自肌肉组织内的其他细胞群,
更新日期:2019-02-27
down
wechat
bug