Despite massive growth in nanomedicine research to date, the field still lacks fundamental understanding of how certain physical and chemical features of a nanoparticle affect its ability to overcome biological obstacles in vivo and reach its intended target. To gain fundamental understanding of how physical and chemical parameters affect the biological outcomes of administered nanoparticles, model systems that can systematically manipulate a single parameter with minimal influence on others are needed. Gold nanoparticles are particularly good model systems in this case as one can synthetically control the physical dimensions and surface chemistry of the particles independently and with great precision. Additionally, the chemical and physical properties of gold allow particles to be detected and quantified in tissues and cells with high sensitivity. Through systematic biological studies using gold nanoparticles, insights toward rationally designed nanomedicine for in vivo imaging and therapy can be obtained. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

中文翻译：

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用金纳米颗粒探测纳米药物的生物学障碍。

尽管迄今为止纳米医学研究的发展迅速，但该领域仍缺乏对纳米颗粒的某些物理和化学特征如何影响其克服体内生物学障碍并达到预定目标的能力的基本了解。为了获得对物理和化学参数如何影响所施用纳米粒子生物学结果的基本了解，需要能够系统地操纵单个参数而对其他参数的影响最小的模型系统。在这种情况下，金纳米颗粒是特别好的模型系统，因为它可以独立且高精度地合成控制颗粒的物理尺寸和表面化学。另外，金的化学和物理特性使组织和细胞中的颗粒被检测到并具有很高的灵敏度。通过使用金纳米颗粒的系统生物学研究，可以获得对合理设计用于体内成像和治疗的纳米药物的见解。本文归类于：生物学的纳米技术方法>生物学中的纳米系统。