Development of an embryo is driven by a series of molecular instructions that control the differentiation of tissue precursor cells and shape the tissues into major body parts. LIM homeobox 1 (LHX1) is a transcription factor that plays a major role in the development of the embryonic head of the mouse. Loss of LHX1 function disrupts the morphogenetic movement of head tissue precursors and impacts on the function of molecular factors in modulating the activity of the WNT signaling pathway. LHX1 acts with a transcription factor complex to regulate the transcription of target genes in multiple phases of development and in a range of embryonic tissues of the mouse and Xenopus. Determining the interacting factors and transcriptional targets of LHX1 will be key to unraveling the ensemble of factors involved in head development and building a head gene regulatory network.

中文翻译：

---

来自LHX1驱动的分子网络在构建胚胎头部中的机理见解。

胚胎的发育受一系列分子指令的驱动，这些指令控制组织前体细胞的分化并将组织塑造为主要的身体部位。LIM homeobox 1（LHX1）是一种转录因子，在小鼠胚胎头的发育中起主要作用。LHX1功能的丧失会破坏头部组织前体的形态发生运动，并影响分子因素在调节WNT信号通路活性中的功能。LHX1与转录因子复合物共同作用，以调节靶基因在小鼠和非洲爪蟾的多个发育阶段以及一系列胚胎组织中的转录。