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Signal Detection and Coding in the Accessory Olfactory System.
Chemical Senses ( IF 3.5 ) Pub Date : 2018-09-27 , DOI: 10.1093/chemse/bjy061
Julia Mohrhardt 1 , Maximilian Nagel 1 , David Fleck 1 , Yoram Ben-Shaul 2 , Marc Spehr 1
Affiliation  

In many mammalian species, the accessory olfactory system plays a central role in guiding behavioral and physiological responses to social and reproductive interactions. Because of its relatively compact structure and its direct access to amygdalar and hypothalamic nuclei, the accessory olfactory pathway provides an ideal system to study sensory control of complex mammalian behavior. During the last several years, many studies employing molecular, behavioral, and physiological approaches have significantly expanded and enhanced our understanding of this system. The purpose of the current review is to integrate older and newer studies to present an updated and comprehensive picture of vomeronasal signaling and coding with an emphasis on early accessory olfactory system processing stages. These include vomeronasal sensory neurons in the vomeronasal organ, and the circuitry of the accessory olfactory bulb. Because the overwhelming majority of studies on accessory olfactory system function employ rodents, this review is largely focused on this phylogenetic order, and on mice in particular. Taken together, the emerging view from both older literature and more recent studies is that the molecular, cellular, and circuit properties of chemosensory signaling along the accessory olfactory pathway are in many ways unique. Yet, it has also become evident that, like the main olfactory system, the accessory olfactory system also has the capacity for adaptive learning, experience, and state-dependent plasticity. In addition to describing what is currently known about accessory olfactory system function and physiology, we highlight what we believe are important gaps in our knowledge, which thus define exciting directions for future investigation.

中文翻译:

附件嗅觉系统中的信号检测和编码。

在许多哺乳动物中,辅助嗅觉系统在指导对社交和生殖相互作用的行为和生理反应中起着核心作用。由于其相对紧凑的结构以及可直接进入杏仁核和下丘脑核,因此,嗅觉辅助途径为研究复杂哺乳动物行为的感觉控制提供了理想的系统。在过去的几年中,许多采用分子,行为和生理学方法的研究大大扩展并增强了我们对该系统的理解。本综述的目的是整合旧的和较新的研究,以提供有关鼻信息和编码的最新和全面的图片,重点是早期的嗅觉辅助系统处理阶段。这些包括在犁鼻器器官中的犁鼻器感觉神经元和附属嗅球的电路。由于绝大多数有关辅助嗅觉系统功能的研究都是使用啮齿动物,因此本综述主要侧重于这种系统发育顺序,尤其是小鼠。两者合计,从较早的文献和较新的研究中出现的新观点是,沿着辅助嗅觉途径的化学感觉信号的分子,细胞和电路特性在许多方面都是独特的。然而,也已经变得明显的是,与主要嗅觉系统一样,辅助嗅觉系统也具有适应性学习,经验和状态依赖可塑性的能力。除了描述目前有关辅助嗅觉系统功能和生理的知识外,
更新日期:2018-09-25
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