To strengthen the detailed understanding of arterial stenosis, we construct a novel hemodynamic model. Frequently used symmetric stenosis is employed in this work. Being different from a traditional model, this numerical model adopts microcirculation resistance as an outlet boundary condition, which is called a seepage condition. Meanwhile, fluid–structure interactions are used in the numerical simulation considering the interrelationship of blood and arterial wall. Our results indicate that (i) the region upstream of stenosis experiences very high pressures during cardiac cycles, (ii) pressure drops much faster as the flow moves into the stenotic region, and (iii) high flow velocities and high shear stresses occur in the post-stenosis region. This work provides evidence that there is a strong effect of the function of microcirculation on stenosis. This contributes to evaluating potential stenotic behavior in arteries and is pivotal in guiding disease treatment.

中文翻译：

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对称性狭窄动脉血流渗流条件和流体-结构相互作用的血流动力学模型

为了加强对动脉狭窄的详细了解，我们构建了一个新的血流动力学模型。在这项工作中采用了经常使用的对称狭窄。与传统模型不同的是，该数值模型采用微循环阻力作为出口边界条件，称为渗流条件。同时，考虑到血液和动脉壁的相互关系，在数值模拟中使用了流固耦合。我们的结果表明 (i) 狭窄上游区域在心动周期中经历了非常高的压力，(ii) 随着血流进入狭窄区域，压力下降得更快，以及 (iii) 高流速和高剪切应力发生在后狭窄区。这项工作提供了证据，证明微循环的功能对狭窄有很强的影响。