Endosomes are dynamic intracellular compartments that control the sorting of a constant stream of different transmembrane cargos either for ESCRT-mediated degradation or for egress and recycling to compartments such as the Golgi and the plasma membrane. The recycling of cargos occurs within tubulovesicular membrane domains and is facilitated by peripheral membrane protein machineries that control both membrane remodelling and selection of specific transmembrane cargos. One of the primary sorting machineries is the Retromer complex, which controls the recycling of a large array of different cargo molecules in cooperation with various sorting nexin (SNX) adaptor proteins. Recently a Retromer-like complex was also identified that controls plasma membrane recycling of cargos including integrins and lipoprotein receptors. Termed "Retriever," this complex uses a different SNX family member SNX17 for cargo recognition, and cooperates with the COMMD/CCDC93/CCDC22 (CCC) complex to form a larger assembly called "Commander" to mediate endosomal trafficking. In this review we focus on recent advances that have begun to provide a molecular understanding of these two distantly related transport machineries.

中文翻译：

---

通过Retromer和Retriever对内体运输的分子理解。

内体是动态的细胞内区室，其控制恒定的不同跨膜货物流的分类，以进行ESCRT介导的降解或用于出口和再循环至高尔基体和质膜等区室。货物的回收发生在肾小管小肠膜区域内，并且通过控制膜重塑和选择特定跨膜货物的外周膜蛋白机制而得以促进。Retromer复合机是主要的分拣设备之一，它与各种分选连接蛋白（SNX）衔接蛋白协同控制大量不同货物分子的回收。最近，还发现了类似Retromer的复合物，该复合物可控制包括整联蛋白和脂蛋白受体在内的货物的质膜回收。被称为“猎犬” 该工厂使用不同的SNX家族成员SNX17进行货物识别，并与COMMD / CCDC93 / CCDC22（CCC）工厂合作以形成更大的组件，称为“指挥官”，以调解内体运输。在这篇综述中，我们关注于最近的进展，这些进展已经开始提供对这两个遥远相关的运输机械的分子理解。