The crucial step in the pathogenic events that lead to the development and the progression of multiple sclerosis (MS) is the infiltration of autoreactive T cells in the brain. Data from experimental autoimmune encephalomyelitis (EAE) mice indicate that, together with microglia, T cells are responsible for the enhancement of the glutamatergic transmission in central neurons, contributing to glutamate‐mediated excitotoxicity, a pathological hallmark of both EAE and MS brains. Here, we addressed the synaptic role of T cells taken from MS patients.

中文翻译：

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来自多发性硬化症患者的外周 T 细胞触发中枢神经元的突触毒性改变

导致多发性硬化症 (MS) 发展和进展的致病事件的关键步骤是大脑中自身反应性 T 细胞的浸润。来自实验性自身免疫性脑脊髓炎 (EAE) 小鼠的数据表明，T 细胞与小胶质细胞一起负责增强中枢神经元的谷氨酸能传递，导致谷氨酸介导的兴奋性毒性，这是 EAE 和 MS 大脑的病理标志。在这里，我们讨论了从 MS 患者身上提取的 T 细胞的突触作用。