Cellular senescence plays a role in organismal ageing and has been linked to persistent DNA damage in age‐related diseases. Brain senescence has been described in astrocytes and microglia, but it is less well understood in neurones. Evidence suggests that neurones activate a senescence‐like mechanism that could contribute to neurodegeneration. We aimed to determine whether a persistent DNA damage response (DDR) and senescence activation are features of motor neurone disease (amyotrophic lateral sclerosis, ALS/MND).

中文翻译：

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p16 和 p21 在 ALS / MND 大脑额叶联合皮层中的表达表明疾病早期的神经元细胞周期失调和星形胶质细胞衰老

细胞衰老在机体衰老中发挥作用，并与年龄相关疾病中的持续 DNA 损伤有关。脑衰老已在星形胶质细胞和小胶质细胞中得到描述，但在神经元中却鲜为人知。有证据表明，神经元激活了一种可能导致神经变性的类似衰老的机制。我们的目的是确定持续的 DNA 损伤反应 (DDR) 和衰老激活是否是运动神经元疾病（肌萎缩性侧索硬化症，ALS/MND）的特征。