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Protein crystal based materials for nanoscale applications in medicine and biotechnology.
WIREs Nanomedicine and Nanobiotechnology ( IF 8.6 ) Pub Date : 2018-11-28 , DOI: 10.1002/wnan.1547
Luke F Hartje 1 , Christopher D Snow 2
Affiliation  

The porosity, order, biocompatibility, and chirality of protein crystals has motivated interest from diverse research domains including materials science, biotechnology, and medicine. Porous protein crystals have the unusual potential to organize guest molecules within highly ordered scaffolds, enabling applications ranging from biotemplating and catalysis to biosensing and drug delivery. Significant research has therefore been directed toward characterizing protein crystal materials in hopes of optimizing crystallization, scaffold stability, and application efficacy. In this overview article, we describe recent progress in the field of protein crystal materials with special attention given to applications in nanomedicine and nanobiotechnology. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.

中文翻译:

基于蛋白质晶体的材料,用于医学和生物技术的纳米级应用。

蛋白质晶体的孔隙度,有序性,生物相容性和手性引起了包括材料科学,生物技术和医学在内的各种研究领域的兴趣。多孔蛋白晶体具有将客体分子组织在高度有序的支架中的非同寻常的潜力,从而使得其应用范围从生物模板化和催化到生物传感和药物传递。因此,重要的研究方向是表征蛋白质晶体材料,以期优化结晶,支架稳定性和应用功效。在这篇概述文章中,我们描述了蛋白质晶体材料领域的最新进展,并特别关注了纳米医学和纳米生物技术中的应用。本文归类于:受生物启发的纳米材料>
更新日期:2019-11-01
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