Discoidin domain receptors, DDR1 and DDR2, are two members of collagen receptor family that belong to tyrosine kinase receptor subgroup. Unlike other matrix receptor-like integrins, these collagen receptors have not been extensively studied. However, more and more studies are focusing on their involvement in cancer. These two receptors are present in several subcellular localizations such as intercellular junction or along type I collagen fibers. Consequently, they are involved in multiple cellular functions, for instance, cell cohesion, proliferation, adhesion, migration and invasion. Furthermore, various signaling pathways are associated with these multiple functions. In this review, we highlight and characterize hallmarks of cancer in which DDRs play crucial roles. We discuss recent data from studies that demonstrate the involvement of DDRs in tumor proliferation, cancer mutations, drug resistance, inflammation, neo-angiogenesis and metastasis. DDRs could be potential targets in cancer and we conclude this review by discussing the different ways to inhibits them.

中文翻译：

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多任务盘状蛋白结构域受体参与多种癌症特征。

Discoidin域受体DDR1和DDR2是胶原蛋白受体家族的两个成员，属于酪氨酸激酶受体亚组。与其他基质受体样整联蛋白不同，这些胶原蛋白受体尚未得到广泛研究。但是，越来越多的研究集中在它们对癌症的参与上。这两个受体存在于几种亚细胞定位中，例如细胞间连接或沿I型胶原纤维。因此，它们参与多种细胞功能，例如细胞内聚，增殖，粘附，迁移和侵袭。此外，各种信号传导途径与这些多功能相关。在这篇综述中，我们重点介绍了DDR在其中起关键作用的癌症的特征。我们讨论了来自研究的最新数据，这些研究表明DDR与肿瘤增殖，癌症突变，耐药性，炎症，新血管生成和转移有关。DDR可能是癌症的潜在靶点，我们通过讨论抑制它们的不同方法来结束本综述。