Extracellular matrix (ECM) provides cells scaffolding for cell migration and microenvironment for various cellular functions. Collagens are major ECM components in tissue and discoidin domain receptors (DDRs) are receptor tyrosine kinases (RTK) that recognise fibrillar collagens. Unlike other RTK, their ligands are solid ECM the that are abundantly present in the pericellular environment in various tissue, and thus its activation and regulations are unique amongst RTK family. It is emerging that DDRs may be the sensors that monitor and detects changes in ECM microenvironment and determines the cellular fates upon tissue injuries. In this mini-review, recent findings on the role of DDRs as microenvironment sensor and their roles in cell migration and invasion are discussed.

中文翻译：

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Discoidin域受体：促进细胞迁移和侵袭的微环境传感器。

细胞外基质（ECM）为细胞迁移提供了细胞支架，为各种细胞功能提供了微环境。胶原蛋白是组织中主要的ECM成分，盘状蛋白结构域受体（DDRs）是识别原纤维胶原蛋白的受体酪氨酸激酶（RTK）。与其他RTK不同，它们的配体是固体ECM，在各种组织的细胞周围环境中大量存在，因此其激活和调控在RTK家族中是独特的。新兴的DDR可能是监视和检测ECM微环境变化并确定组织受伤时细胞命运的传感器。在此小型审查中，讨论了有关DDR作为微环境传感器的作用及其在细胞迁移和侵袭中的作用的最新发现。