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Domain-specific cognitive effects of white matter pathology in old age, mild cognitive impairment and Alzheimer's disease.
Aging, Neuropsychology, and Cognition ( IF 2.102 ) Pub Date : 2019-06-14 , DOI: 10.1080/13825585.2019.1628916
Alar Kaskikallio 1 , Mira Karrasch 1 , Juha O Rinne 2, 3 , Terhi Tuokkola 2 , Riitta Parkkola 4 , Petra Grönholm-Nyman 1
Affiliation  

Concomitant white matter (WM) brain pathology is often present in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cognitive effects of WM pathology on cognition in normal and pathological aging have been studied, but very little is known about possible group-specific effects in old age, MCI and AD. The purpose of the current study was to examine the relationship between WM pathology and cognitive functioning in four cognitive domains in old age, MCI and AD. The study utilized multi-domain neuropsychological data and visually rated MRI imaging data from a sample of 56 healthy older adults, 40 patients with MCI and 52 patients with AD (n = 148). After controlling for age and education, main effects of frontal WM pathology (especially in the left hemisphere) were found for cognitive performances in two domains, whereas a main effect of parieto-occipital WM pathology was only found for processing speed. In addition, with regard to processing speed, an interaction between group and WM changes was found: Patients with AD that had moderate or severe left frontal WM pathology were considerably slower than patients with AD that had milder cerebrovascular pathology. Frontal WM pathology, especially in the left hemisphere, seems to affect cognitive functions in many domains in all three groups. The results of the study increase our knowledge of cognitive repercussions stemming from frontal and/or parieto-occipital WM pathology in AD. Clinicians should be aware that patients with AD with prominent frontal cerebrovascular pathology can have considerably slowed cognitive processing.

中文翻译:

白质病在老年,轻度认知障碍和阿尔茨海默氏病方面的特定领域认知作用。

患有轻度认知障碍(MCI)和阿尔茨海默氏病(AD)的患者经常出现伴随的白质(WM)脑病理。已经研究了WM病理学对正常和病理性衰老过程中认知的认知作用,但对于老年,MCI和AD的可能的群体特异性作用知之甚少。本研究的目的是在老年人,MCI和AD的四个认知领域中检验WM病理学与认知功能之间的关系。该研究利用了来自56名健康老年人,40名MCI患者和52名AD患者(n = 148)的样本的多域神经心理学数据和MRI图像视觉评级。在控制了年龄和教育程度之后,发现了额叶WM病理学(尤其是在左半球)对认知表现的两个主要影响,而顶枕WM病理学的主要作用只是为了提高处理速度。另外,关于处理速度,发现组和WM变化之间存在相互作用:具有中度或重度左额叶WM病理的AD患者比具有轻度脑血管病理的AD患者慢得多。额叶WM病理,尤其是在左半球,似乎在所有这三个组的许多领域都影响认知功能。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。另外,关于处理速度,发现组和WM变化之间存在相互作用:具有中度或重度左额叶WM病理的AD患者比具有轻度脑血管病理的AD患者慢得多。额叶WM病理,尤其是在左半球,似乎在所有这三个组的许多领域都影响认知功能。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。另外,关于处理速度,发现组和WM变化之间存在相互作用:具有中度或重度左额叶WM病理的AD患者比具有轻度脑血管病理的AD患者慢得多。额叶WM病理,尤其是在左半球,似乎在所有这三个组的许多领域都影响认知功能。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。具有中度或重度左额叶WM病理的AD患者比具有轻度脑血管病理的AD患者慢得多。额叶WM病理,尤其是在左半球,似乎在所有这三个组的许多领域都影响认知功能。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。具有中度或重度左额叶WM病理的AD患者比具有轻度脑血管病理的AD患者慢得多。额叶WM病理,尤其是在左半球,似乎在所有这三个组的许多领域都影响认知功能。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。该研究结果增加了我们对额叶和/或顶枕WM病理学引起的认知反应的认识。临床医生应注意,患有额叶脑血管病理突出的AD患者可大大减慢认知过程。
更新日期:2019-11-01
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