Abstract

Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC₅₀ value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3–25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1–17 and 21–25 were evaluated for their α-glucosidase inhibitory activities. Compound 11 was the most active ones with an IC₅₀ values of 83.4 μM. These results verify the α-glucosidase inhibitory activity of M. haplocalyx (M. canadensis) and specify its active compounds for the first time.

Graphical Abstract

中文翻译：

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Mentha haplocalyx Briq 的化学成分。（Mentha canadensis L.）及其 α-葡萄糖苷酶抑制活性。

摘要

薄荷（Mentha canadensis）作为中药中广泛使用的药用植物，其地上部分提取物被发现能显着抑制α-葡萄糖苷酶的活性，IC 50 值为_21.0 μg/mL。以生物活性为指导的提取物分离得到了两种新化合物（1和2），以及 23 种已知化合物（3 – 25）。它们的结构是通过广泛的光谱分析（1D 和 2D NMR、MS、IR 和 UV）确定的。评估了化合物1 – 17和21 – 25的 α-葡萄糖苷酶抑制活性。化合物11是最活跃的化合物，IC ₅₀值为 83.4 μM。这些结果验证了M. haplocalyx ( M. canadensis )的α-葡萄糖苷酶抑制活性，并首次明确了其活性化合物。

图形概要