Abstract

Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability.

Graphical Abstract

中文翻译：

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太子参根中的两种新的C21甾族糖苷。

摘要

从Cynanchum paniculatum（Bge。）Kitag的根中分离出两个新的C21类固醇糖苷，Paniculatumosides H和I，以及四个已知的糖苷。通过包括广泛的1D和2D NMR技术在内的光谱方法鉴定了它们的结构。对所有化合物进行抗烟草花叶病毒（TMV）活性及其对三种人类肿瘤细胞系（SMMC-7721，MDA-MB-231和A549）的细胞毒性的检测。结果表明，化合物1和5表现出强效的保护活性抗TMV，而2，4和6具有在SMMC-7721癌细胞存活力中度影响。

图形概要