The authors reply: Letter on: “Pitfalls in the measurement of muscle mass: a need for a reference standard” by Clark et al.,Journal of Cachexia Sarcopenia and Muscle

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The authors reply: Letter on: “Pitfalls in the measurement of muscle mass: a need for a reference standard” by Clark et al.
Journal of Cachexia Sarcopenia and Muscle Pub Date : 2019-01-30 , DOI: 10.1002/jcsm.12387
Fanny Buckinx ₁ , Francesco Landi ₂ , Matteo Cesari _{3,

4} , Roger A Fieding ₅ , Marjolein Visser _{6,

7} , Klaus Engelke ₈ , Stefania Maggi ₉ , Elaine Dennison ₁₀ , Nasser M Al-Daghri ₁₁ , Sophie Allepaerts ₁₂ , Jurgen Bauer ₁₃ , Ivan Bautmans ₁₄ , Maria-Luisa Brandi ₁₅ , Olivier Bruyère ₁ , Tommy Cederholm ₁₆ , Francesca Cerreta ₁₆ , Antonio Cherubini ₁₇ , Cyrus Cooper _{10,

18} , Alphonso Cruz-Jentoft ₁₉ , Eugene McCloskey _{20,

21} , Bess Dawson-Hughes ₂₂ , Jean-Marc Kaufman ₂₃ , Andrea Laslop ₂₄ , Jean Petermans ₁₂ , Jean-Yves Reginster ₁ , René Rizzoli ₂₅ , Sian Robinson _{10,

26} , Yves Rolland ₂₇ , Ricardo Rueda ₂₈ , Bruno Vellas ₂₇ , John A Kanis _{20,

29}

Affiliation

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Milan, Italy.
Gérontopôle, University Hospital of Toulouse, Toulouse, France.
INSERM UMR1027, University of Toulouse III Paul Sabatier, Toulouse, France.
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Department of Health Sciences, VU University Amsterdam, Amsterdam, Netherlands.
Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, Netherlands.
Institute of Medical Physics, University of Erlangen, Erlangen, Germany.
National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Department of Geriatrics, CHU-Liège, Liège, Belgium.
Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Oldenburg, Germany.
Gerontology and Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Department of Surgery and Translational Medicine, University of Florence, Florence, 59139, Italy.
Human Medicines Research and Development Support Division, Scientific Advice, London, UK.
Geriatrics and Geriatric Emergency Care, IRCCS-INRCA, Ancona, Italy.
NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.
Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain.
Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
MRC and Arthritis Research UK Centre for Integrated research in Musculoskeletal Ageing (CIMA), London, UK.
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium.
Scientific Office, Austrian Agency for Health and Food Safety, Vienna, Austria.
Service of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital, Southampton NHS Foundation Trust, Southampton, UK.
Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse); UMR INSERM 1027, University of Toulouse III, Toulouse, France.
Abbott Nutrition R&D, Granada, Spain.
Institute of Health and Ageing, Australian Catholic University, Melbourne, Australia.

AbstractHowever, semantics aside, we think that DXA can indeed serve as a reference standard for measuring muscle mass. Obviously, CT and MRI are advanced techniques that can and have been used to obtain important information such as muscle size/volume and more recently amount and distribution of intra‐ and intermuscular adipose tissue. Also individual muscles can be assessed separately. However, with respect to muscle mass, the comparison of DXA with CT/MRI is rather difficult because DXA and QCT/MRI measure different physical parameters

中文翻译：

作者回复：克拉克等人写的信：“肌肉质量测量的陷阱：需要参考标准”。

摘要然而，撇开语义不谈，我们认为 DXA 确实可以作为测量肌肉质量的参考标准。显然，CT 和 MRI 是先进技术，可以并且已经用于获取重要信息，例如肌肉大小/体积以及最近的肌内和肌间脂肪组织的数量和分布。还可以单独评估个体肌肉。然而，就肌肉质量而言，DXA 与 CT/MRI 的比较相当困难，因为 DXA 和 QCT/MRI 测量的物理参数不同

更新日期：2019-01-30

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