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The ups and downs of S. aureus nasal carriage.
Mathematical Medicine and Biology ( IF 1.1 ) Pub Date : 2019-06-13 , DOI: 10.1093/imammb/dqy006
Angela M Jarrett 1 , Nicholas G Cogan 2
Affiliation  

Staphylococcus aureus infections are a growing concern worldwide due to the increasing number of strains that exhibit antibiotic resistance. Recent studies have indicated that some percentage of people carry the bacteria in the nasal cavity and therefore are at a higher risk of subsequent, and more serious, infections in other parts of the body. However, individuals carrying the infection can be classified as only intermittent carriers versus persistent carriers, being able to eliminate the bacteria and later colonized again. Using a model of bacterial colonization of the anterior nares, we investigate oscillatory patterns related to intermittent carriage of S. aureus. Following several studies using global sensitivity analysis techniques, various insights into the model's behaviour were made including interacting effects of the bacteria's growth rate and movement in the mucus, suggesting parameter connections associated with biofilm-like behaviour. Here the bacterial growth rate and bacterial movement are explicitly connected, leading to expanded oscillatory behaviour in the model. We suggest possible implications that this oscillatory behaviour can have on the definition of intermittent carriage and discuss differences in the bacterial virulence dependent upon individual host health. Furthermore, we show that connecting the bacterial growth and movement also expands the region of the parameter space for which the bacteria are able to survive and persist.

中文翻译:

金黄色葡萄球菌鼻托的起伏。

由于表现出抗生素抗性的菌株数量的增加,金黄色葡萄球菌感染在全世界引起越来越多的关注。最近的研究表明,一定比例的人在鼻腔中携带细菌,因此在身体其他部位发生随后更严重的感染的风险更高。但是,携带感染的个体可以分为仅间歇性携带者与持久性携带者,能够消灭细菌并随后再次定殖。使用前鼻孔细菌定殖的模型,我们调查与金黄色葡萄球菌的间歇运输有关的振荡模式。在使用全局敏感性分析技术进行了几项研究之后,对模型行为的各种见解得到了包括细菌细菌相互作用的影响。黏液的生长速率和运动,提示与生物膜样行为相关的参数联系。在这里,细菌的生长速度和细菌的运动是明确相关的,从而导致模型中的振荡行为扩大。我们建议这种振荡行为可能对间歇运输的定义可能产生的影响,并讨论取决于个体宿主健康的细菌毒力的差异。此外,我们表明连接细菌的生长和运动也扩大了细菌能够生存和持久存在的参数空间区域。导致模型中的振荡行为扩展。我们建议这种振荡行为可能对间歇运输的定义可能产生的影响,并讨论取决于个体宿主健康的细菌毒力的差异。此外,我们表明连接细菌的生长和运动也扩大了细菌能够生存和持久存在的参数空间区域。导致模型中的振荡行为扩展。我们建议这种振荡行为可能对间歇运输的定义可能产生的影响,并讨论取决于个体宿主健康的细菌毒力的差异。此外,我们表明连接细菌的生长和运动也扩大了细菌能够生存和持久存在的参数空间区域。
更新日期:2019-11-01
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