Notch, LIN-12, and GLP-1 are receptors that mediate a broad range of cell interactions during Drosophila and nematode development. Signaling by these receptors relies on a conserved pathway with three core components: DSL ligand, LNG receptor, and a CSL effector that links the receptor to its transcriptional response. Although key functional regions have been identified in each class of proteins, the mechanism for signal transduction is not yet understood. Diverse regulatory mechanisms influence signaling by the LIN-12/Notch pathway. Inductive signaling relies on the synthesis of ligand and receptor in distinct but neighboring cells. By contrast, lateral signaling leads to the transformation of equivalent cells that express both ligand and receptor into nonequivalent cells that express either ligand or receptor. This transformation appears to rely on regulatory feedback loops within the LIN-12/Notch pathway. In addition, the pathway can be regulated by intrinsic factors that are asymmetrically segregated during cell division or by extrinsic cues via other signaling pathways. Specificity in the pathway does not appear to reside in the particular ligand or receptor used for a given cell-cell interaction. The existence of multiple ligands and receptors may have evolved from the stringent demands placed upon the regulation of genes encoding them.

中文翻译：

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LIN-12 / Notch信号通路及其调控。

Notch，LIN-12和GLP-1是在果蝇和线虫发育过程中介导广泛细胞相互作用的受体。这些受体发出的信号依赖于具有三个核心成分的保守途径：DSL配体，LNG受体和将受体与其转录反应联系起来的CSL效应子。尽管在每一类蛋白质中都已确定了关键的功能区，但信号转导的机制尚未被了解。多种调节机制通过LIN-12 / Notch途径影响信号传导。诱导信号转导依赖于不同但相邻细胞中配体和受体的合成。相反，横向信号传导导致表达配体和受体的等效细胞转化为表达配体或受体的非等效细胞。这种转变似乎依赖于LIN-12 / Notch途径内的调节反馈回路。另外，该途径可以由在细胞分裂过程中不对称分离的内在因子或通过其他信号途径的外在信号调节。该途径的特异性似乎不存在于用于给定细胞-细胞相互作用的特定配体或受体中。多种配体和受体的存在可能是由于对编码它们的基因的调控提出了严格的要求。该途径的特异性似乎不存在于用于给定细胞-细胞相互作用的特定配体或受体中。多种配体和受体的存在可能是由于对编码它们的基因的调控提出了严格的要求。该途径的特异性似乎不存在于用于给定细胞-细胞相互作用的特定配体或受体中。多种配体和受体的存在可能是由于对编码它们的基因的调控提出了严格的要求。