The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response.

中文翻译：

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先天性B细胞：保护性免疫细胞的原型。

先天的B细胞（IBC）群体是异质的，并参与主要的免疫反应。IBC功能包括产生具有IgM同种型的天然抗体的高能力，消除凋亡细胞的能力以及对T细胞的同源帮助能力。在IBC子集中，B-1细胞和边缘区B细胞是IgM的主要产生者，起着快速免疫应答的作用，可能会在感染后不久重新定位为卵泡淋巴样并分化为细胞因子和抗体分泌细胞。中型散货箱的功能高度依赖于其定位位点和其B细胞受体组成的性质，表明不同免疫反应的可塑性范围很高。在这篇综述中，我们将首先在小鼠中然后在人类中描述不同的先天性B细胞亚群的性质和功能。除此之外，