We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N = 119), Ciudad Juárez (N = 106) and rural communities (N = 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 ± 0.88% by ML; 41.53% of European haplotypes) and Native American (39.51 ± 2.17% by ML; 37.45% of Native American haplotypes), while African genetic component was less apparent (8.36 ± 1.47% by ML; 11.70% of African haplotypes).

我们研究了HLA I类（HLA-A，-B）和II类（HLA-DRB1，-DQB1）基于PCR-SSP的等位基因在来自奇瓦瓦州（N = 119），华雷斯城（N = 106）和农村社区（N = 236）的奇瓦瓦州的墨西哥人中进行分类，以获得有关等位基因和单倍型频率的信息以及它们之间的联系不平衡。我们发现，在奇瓦瓦州发现的最常见单倍型包括七个美洲原住民和三个欧洲单倍型。混合物估计显示，奇瓦瓦州的主要遗传成分是欧洲的（ML的52.12±0.88％；欧洲的单倍型的41.53％）和美洲原住民的（ML的39.51±2.17％；美国原住民的37.45％的单倍型），而非洲的遗传成分是较不明显（按ML计为8.36±1.47％；非洲单倍型的11.70％）。