Advanced biomedical diagnostic technologies fulfill an important role in improving health and well-being in society. A large number of excellent technologies have already been introduced and have given rise to the "lab-on-a-chip" paradigm. Most of these technologies, however, require additional instrumentation for interfacing and readout, so they are often confined to the laboratory and are not suitable for use in the field or in wider clinical practice. Other technologies require a light coupling element, such as a grating coupler or a fiber coupler, which complicates packaging. Here, we introduce a novel biosensor based on a chirped guided-mode resonant grating. The chirped grating combines the sensing function with the readout function by translating spectral information into spatial information that is easily read out with a simple CMOS camera. We demonstrate a refractive index sensitivity of 137 nm/RIU and an extrapolated limit of detection of 267 pM for the specific binding of an immunoglobulin G antibody. The chirped guided-mode resonance approach introduces a new degree of freedom for sensing biomedical information that combines high sensitivity with autonomous operation. We estimate that the cost of components is U.S. $10 or less when mass manufactured, so the technology has the potential to truly transform point-of-care applications.

中文翻译：

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guided导模共振生物传感器。

先进的生物医学诊断技术在改善社会健康和福祉方面发挥着重要作用。已经引入了许多优秀的技术，并且产生了“芯片实验室”的范例。但是，大多数这些技术都需要用于连接和读出的附加仪器，因此它们通常仅限于实验室，不适合在现场或更广泛的临床实践中使用。其他技术需要使封装复杂化的光耦合元件，例如光栅耦合器或光纤耦合器。在这里，我们介绍一种基于a导模谐振光栅的新型生物传感器。grating光栅将光谱信息转换为空间信息，从而将传感功能与读出功能结合在一起，而该空间信息可以通过简单的CMOS相机轻松读出。我们证明了137 nm / RIU的折射率敏感性和267 pM的免疫球蛋白G抗体特异性结合的检测极限的推断。guided引导模式共振方法为传感生物医学信息引入了新的自由度，该自由度将高灵敏度与自主操作相结合。我们估计，批量生产时组件的成本为10美元或更少，因此该技术具有真正改变即时医疗应用的潜力。我们证明了137 nm / RIU的折射率敏感性和267 pM的免疫球蛋白G抗体特异性结合的检测极限的推断。guided引导模式共振方法为传感生物医学信息引入了新的自由度，该自由度将高灵敏度与自主操作相结合。我们估计，批量生产时组件的成本为10美元或更少，因此该技术具有真正改变即时医疗应用的潜力。我们证明了137 nm / RIU的折射率敏感性和267 pM的免疫球蛋白G抗体特异性结合的检测极限的推断。guided引导模式共振方法为传感生物医学信息引入了新的自由度，该自由度将高灵敏度与自主操作相结合。我们估计，批量生产时组件的成本为10美元或更少，因此该技术具有真正改变即时医疗应用的潜力。