One of the most common age-related neurodegenerative disorders is Alzheimer’s disease which globally threatening the health of elderly people. Although there are several pharmacological and non- pharmacological treatments for Alzheimer’s disease, they can just decrease the symptoms in these diseases. In this context, cell therapy and regenerative medicine approach as the novel therapeutic strategies for neurodegenerative diseases would be important. Based on scientific research principles, using any novel therapeutic approaches before the run in clinical trials need to take preclinical (animal study) stapes. Accordingly, an animal study can improve our understanding of biological mechanisms of diseases and as an important step should adhering to ethical guidelines and standards. On the other hand, to gain suitable outcomes, it is important to check the appropriate validation of animal models. In this regard, the present review would discuss about the development and validation of appropriate AD animal models in the field of regenerative medicine.

中文翻译：

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用于再生医学的阿尔茨海默氏病动物模型的开发和验证。

与年龄相关的最常见的神经退行性疾病之一是阿尔茨海默氏病，该病在全球范围内威胁着老年人的健康。尽管对于阿尔茨海默氏病有几种药物学和非药物学治疗方法，但是它们可以减轻这些疾病的症状。在这种情况下，作为神经退行性疾病的新型治疗策略的细胞疗法和再生医学方法将很重要。基于科学研究原则，在临床试验进行之前使用任何新颖的治疗方法都需要进行临床前（动物研究）骨。因此，进行动物研究可以增进我们对疾病生物学机制的理解，并且作为重要步骤，应遵守道德准则和标准。另一方面，为了获得合适的结果，重要的是要检查动物模型的适当验证。在这方面，本综述将讨论再生医学领域合适的AD动物模型的开发和验证。