Hypertension is one of the most important risk factors and a leading cause of death from cardiovascular and cerebrovascular diseases. Based on numerous previous studies, hypertension is thought to be caused by the complex mutual interactions of genetic factors and environmental factors, such as excessive salt intake and stress. However, its detailed mechanisms are not yet clearly understood. The renin-angiotensin system (RAS) is a key hormonal system in the pathogenesis of hypertension. New knowledge is still accruing on this cascade, even after more than 120 years since the discovery of renin. To clarify the molecular mechanisms of RAS in vivo, we created transgenic mice with chronic hypertension. These mice carry the human genes encoding renin, a hypertensive enzyme, and its substrate angiotensinogen. Hypotensive mice homozygous for a targeted disruption of the angiotensinogen gene were also created. This review presents our 47-year history of RAS research.

中文翻译：

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肾素-血管紧张素系统研究：从分子到全身。

高血压是最重要的危险因素之一，也是心血管和脑血管疾病致死的主要原因。根据许多先前的研究，高血压被认为是由遗传因素和环境因素（例如盐摄入过多和压力）之间复杂的相互作用所引起的。但是，其详细的机制尚不清楚。肾素-血管紧张素系统（RAS）是高血压发病机制中的关键激素系统。即使从发现肾素以来已有120多年了，这种级联仍在积累新知识。为了阐明体内RAS的分子机制，我们创建了具有慢性高血压的转基因小鼠。这些小鼠携带编码肾素，高血压酶及其底物血管紧张素原的人类基因。还创建了针对血管紧张素原基因靶向破坏的纯合性低血压小鼠。这篇评论介绍了我们47年的RAS研究历史。