Amongst the regulators of voltage-gated ion channels is the collapsin response mediator protein 2 (CRMP2). CRMP2 regulation of the activity and trafficking of NaV1.7 voltage-gated sodium channels as well as the N-type (CaV2.2) voltage-gated calcium channel (VGCC) has been reported. On the other hand, CRMP2 does not appear to regulate L- (CaV1.x), P/Q- (CaV2.1), and R- (CaV2.3) type high VGCCs. Whether CRMP2 regulates low VGCCs remains an open question. Here, we asked if CRMP2 could regulate the low voltage-gated (T-type/CaV3.x) channels in sensory neurons. Reducing CRMP2 protein levels with short interfering RNAs yielded no change in macroscopic currents carried by T-type channels. No change in biophysical properties of the T-type currents was noted. Future studies pursuing CRMP2 druggability in neuropathic pain will benefit from the findings that CRMP2 regulates only the N-type (CaV2.2) calcium channels.

在电压门控离子通道的调节剂中，是胶原蛋白反应介导蛋白2（CRMP2）。已经报道了CRMP2调节NaV1.7电压门控钠通道以及N型（CaV2.2）电压门控钙通道（VGCC）的活性和运输。另一方面，CRMP2似乎不调节L-（CaV1.x），P / Q-（CaV2.1）和R-（CaV2.3）型高VGCC。CRMP2是否调节低VGCC仍是一个悬而未决的问题。在这里，我们问CRMP2是否可以调节感觉神经元中的低电压门控（T型/CaV3.x）通道。用短干扰RNA降低CRMP2蛋白水平不会改变T型通道携带的宏观电流。没有注意到T型电流的生物物理特性的变化。