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Toll-like receptors.
Annual Review of Immunology ( IF 29.7 ) Pub Date : 2003-01-14 , DOI: 10.1146/annurev.immunol.21.120601.141126
Kiyoshi Takeda 1 , Tsuneyasu Kaisho , Shizuo Akira
Affiliation  

The innate immune system in drosophila and mammals senses the invasion of microorganisms using the family of Toll receptors, stimulation of which initiates a range of host defense mechanisms. In drosophila antimicrobial responses rely on two signaling pathways: the Toll pathway and the IMD pathway. In mammals there are at least 10 members of the Toll-like receptor (TLR) family that recognize specific components conserved among microorganisms. Activation of the TLRs leads not only to the induction of inflammatory responses but also to the development of antigen-specific adaptive immunity. The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor molecule MyD88. However, there is evidence for additional pathways that mediate TLR ligand-specific biological responses.

中文翻译:

Toll样受体。

果蝇和哺乳动物的先天免疫系统使用Toll受体家族来感知微生物的入侵,对其进行刺激会引发一系列宿主防御机制。在果蝇中,抗微生物反应依赖于两个信号传导途径:Toll途径和IMD途径。在哺乳动物中,Toll样受体(TLR)家族至少有10个成员可以识别微生物中保守的特定成分。TLR的激活不仅导致炎症反应的诱导,而且导致抗原特异性适应性免疫的发展。TLR诱导的炎症反应取决于适配器分子MyD88介导的常见信号通路。但是,有证据表明介导TLR配体特异性生物反应的其他途径。
更新日期:2019-11-01
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