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Analysis of twin of eyeless regulation during early embryogenesis in Drosophila melanogaster.
Gene Expression Patterns ( IF 1.2 ) Pub Date : 2008-07-01 , DOI: 10.1016/j.gep.2008.06.002
Jorge Blanco 1 , Walter J Gehring
Affiliation  

The Drosophila Pax6 homolog twin of eyeless (toy) is so far the first zygotically expressed gene involved in eye morphogenesis in Drosophila. The study of its expression during embryogenesis is therefore informative of the initial events of eye development in Drosophila. We have analyzed how the initial expression domain of toy at cellular blastoderm is regulated. We show that the three maternal patterning systems active in the cephalic region (the anterior, terminal and dorsal-ventral systems) cooperate with zygotically activated gap genes to shape the initial expression domain of toy. Whereas Bicoid, Dorsal and Torso signaling synergistically act as activators, Hunchback, Knirps and Decapentaplegic act as repressors.

中文翻译:

分析果蝇早期胚胎发生过程中的双眼调节。

无眼(玩具)的果蝇Pax6同源双胞胎是迄今为止第一个在果蝇中参与眼睛形态发生的自发表达基因。因此,研究其在胚胎发生过程中的表达可为果蝇眼发育的初始事件提供信息。我们已经分析了如何在细胞胚盘处调节玩具的初始表达域。我们显示活跃在头颅区域(前,末端和背-腹侧系统)的三个孕产妇图案系统与合子激活的差距基因合作塑造玩具的初始表达域。Bicoid,背侧和躯干信号协同起激活剂作用,驼背,Knirps和Decapentaplegic起到阻遏剂作用。
更新日期:2019-11-01
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