Background: Titanium biomedical devices coated with strontium-doped calcium phosphate ceramics can support desirable bone regeneration through anabolic and anti-catabolic effects of strontium and the compositions close to that of natural mineral tissue. Methods: Strontium was doped into the calcium phosphate coating using the cyclic pre-calcification method on the anodized titanium plate. The effects of the different concentration of strontium in treatment solution and cycle numbers of the pre-calcification treatment on the biocompatibility were investigated in terms of the changes in morphology and chemical composition of coating, ion release pattern and cytocompatibility in vitro. Results: At a high substitution ratio of strontium in the calcium phosphate coating, the size of precipitated particles was decreased and the solubility of the coating was increased. ASH55 group, which was coated by pre-calcification treatment of 20 cycles in coating solution with Sr:Ca molar ratio of 5:5, exhibited superior cellular attachment at 1 day and proliferation after 7 days of culturing in comparison with the non-doped surface and other doped surfaces. Conclusion: Sufficient strontium doping concentrations in calcium phosphate coating can enhance cell adhesion and proliferation on the titanium biomedical devices for bone regeneration.

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锶掺杂对磷酸钙涂层钛基体生物相容性的影响

背景：涂有掺锶磷酸钙陶瓷的钛生物医学装置可以通过锶的合成代谢和抗分解代谢作用以及接近天然矿物质组织的成分来支持理想的骨再生。方法：采用循环预钙化法在阳极氧化钛板上将锶掺杂到磷酸钙涂层中。从涂层的形态和化学成分的变化、离子释放模式和体外细胞相容性等方面研究了不同处理溶液中锶浓度和预钙化处理循环次数对生物相容性的影响。结果：在磷酸钙涂层中锶的高取代率下，沉淀颗粒的尺寸减小，涂层的溶解度增加。ASH55 组在 Sr:Ca 摩尔比为 5:5 的包被溶液中预钙化处理 20 个循环，与未掺杂的表面相比，在第 1 天时表现出优异的细胞附着和在培养 7 天后的增殖和其他掺杂表面。结论：磷酸钙涂层中足够的锶掺杂浓度可以增强用于骨再生的钛生物医疗器械上的细胞粘附和增殖。与未掺杂的表面和其他掺杂的表面相比，在 1 天时表现出优异的细胞附着和在培养 7 天后的增殖。结论：磷酸钙涂层中足够的锶掺杂浓度可以增强用于骨再生的钛生物医疗器械上的细胞粘附和增殖。与未掺杂的表面和其他掺杂的表面相比，在 1 天时表现出优异的细胞附着和在培养 7 天后的增殖。结论：磷酸钙涂层中足够的锶掺杂浓度可以增强用于骨再生的钛生物医疗器械上的细胞粘附和增殖。