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Long-Term Taste Impairment after Intensity-Modulated Radiotherapy to Treat Head-and-Neck Cancer: Correlations with Glossectomy and the Mean Radiation Dose to the Oral Cavity.
Chemical Senses ( IF 3.5 ) Pub Date : 2019-04-09 , DOI: 10.1093/chemse/bjz018
Wen-Cheng Chen,Ming-Shao Tsai,Yao-Te Tsai,Chia-Hsuan Lai,Chuan-Pin Lee,Miao-Fen Chen

We explored the effects of various parameters on taste impairments (TIs) in head-and-neck (H&N) cancer patients receiving intensity-modulated radiotherapy (IMRT). From January 2014 to September 2017, 88 H&N cancer patients subjected to curative or postoperative IMRT were enrolled in this prospective study. All patients underwent at least 1 year of follow-up after IMRT. Quality-of-life assessments in terms of patient-reported gustatory function were measured using the taste-related questions of the European Organization for Research and Treatment of Cancer H&N35 questionnaires. At a median follow-up time of 27 months, 27 of 88 patients (30.7%) reported long-term TIs. In multivariate analyses, glossectomy most significantly predicted TIs (P = 0.04). The percentage of TIs (61.5%) was significantly (P = 0.03) higher in patients who underwent partial or total glossectomy than in patients who did not undergo surgery (28.0%) and those who underwent radical surgery without glossectomy (20.0%). When we excluded surgical patients from analyses, the mean radiation dose to the oral cavity was of borderline significance in terms of TI prediction (P = 0.05). Only 14.3% of patients suffered from TIs when the mean radiation dose was <5000 centi-Gray (cGy) compared with 28.3% when the mean dose was ≥5000 cGy. In conclusion, glossectomy is the major cause of long-term TIs in H&N cancer patients receiving IMRT. In patients who do not undergo glossectomy, reduction of the mean radiation dose to the oral cavity may reduce TIs after IMRT.

中文翻译:

调强放疗治疗头颈癌后的长期味觉障碍:与舌切除术和口腔平均辐射剂量的关系。

我们探索了各种参数对接受调强放疗(IMRT)的头颈(H&N)癌症患者的味觉损害(TI)的影响。从2014年1月到2017年9月,本研究纳入了88例接受根治性或术后IMRT治疗的H&N癌症患者。所有患者均在IMRT后接受了至少1年的随访。使用欧洲癌症研究与治疗组织H&N35问卷中与味觉相关的问题,测量了患者报告的味觉功能方面的生活质量评估。在27个月的中位随访时间中,88例患者中有27例(30.7%)报告了长期的TI。在多变量分析中,舌状切除术最能预测TI(P = 0.04)。TI的百分比(61.5%)显着(P = 0。03)接受部分或全部舌切除术的患者比未接受手术的患者(28.0%)和接受不进行舌切除术的根治性手术的患者(20.0%)高。当我们从分析中排除手术患者时,就TI预测而言,对口腔的平均辐射剂量具有临界意义(P = 0.05)。当平均辐射剂量<5000厘泊(cGy)时,只有14.3%的患者患有TIs,而当平均辐射剂量≥5000cGy时则为28.3%。总之,在接受IMRT的H&N癌症患者中,舌状切除术是长期TI的主要原因。在未进行舌切除术的患者中,降低IMRT后向口腔的平均放射剂量可能会减少TI。0%)和接受了不进行舌切除术的根治性手术的患者(20.0%)。当我们从分析中排除手术患者时,就TI预测而言,对口腔的平均辐射剂量具有临界意义(P = 0.05)。当平均辐射剂量<5000厘泊(cGy)时,只有14.3%的患者患有TIs,而当平均辐射剂量≥5000cGy时则为28.3%。总之,在接受IMRT的H&N癌症患者中,舌状切除术是长期TI的主要原因。在未进行舌切除术的患者中,降低IMRT后向口腔的平均放射剂量可能会减少TI。0%)和接受了不进行舌切除术的根治性手术的患者(20.0%)。当我们从分析中排除手术患者时,就TI预测而言,对口腔的平均辐射剂量具有临界意义(P = 0.05)。当平均辐射剂量<5000厘泊(cGy)时,只有14.3%的患者患有TIs,而当平均辐射剂量≥5000cGy时则为28.3%。总之,在接受IMRT的H&N癌症患者中,舌状切除术是长期TI的主要原因。在未进行舌切除术的患者中,降低IMRT后向口腔的平均放射剂量可能会减少TI。当平均辐射剂量<5000厘泊(cGy)时,有3%的患者患有TIs,而当平均辐射剂量≥5000cGy时为28.3%。总之,在接受IMRT的H&N癌症患者中,舌状切除术是长期TI的主要原因。在未进行舌切除术的患者中,降低IMRT后向口腔的平均放射剂量可能会减少TI。当平均辐射剂量<5000厘泊(cGy)时,有3%的患者患有TIs,而当平均辐射剂量≥5000cGy时为28.3%。总之,在接受IMRT的H&N癌症患者中,舌状切除术是长期TI的主要原因。在未进行舌切除术的患者中,降低IMRT后向口腔的平均放射剂量可能会减少TI。
更新日期:2019-11-01
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