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Genetic variants in microRNAs are associated with cervical cancer risk.
Mutagenesis ( IF 2.7 ) Pub Date : 2019-05-29 , DOI: 10.1093/mutage/gez005 Shizhi Wang 1 , Haixia Zhu 2 , Bo Ding 3 , Xinrui Feng 1 , Wenxuan Zhao 1 , Mengjing Cui 1 , Yuling Xu 1 , Minxin Shi 4 , Jian Chen 2 , Hua Jin 2
Mutagenesis ( IF 2.7 ) Pub Date : 2019-05-29 , DOI: 10.1093/mutage/gez005 Shizhi Wang 1 , Haixia Zhu 2 , Bo Ding 3 , Xinrui Feng 1 , Wenxuan Zhao 1 , Mengjing Cui 1 , Yuling Xu 1 , Minxin Shi 4 , Jian Chen 2 , Hua Jin 2
Affiliation
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility. Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls. The results showed that the miR-149 rs2292832 TC/CC genotypes were associated with a 21% increased risk of CC compared with the TT genotype [odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.00-1.47]. The association was more prominent among the subjects with age ≤ 48 years (OR = 1.55, 95% CI = 1.16-2.06), having history of abortion (OR = 1.44, 95% CI = 1.12-1.86), premenopausal status (OR = 1.41, 95% CI = 1.08-1.85) and patients with clinical stage II of CC (OR = 1.43, 95% CI = 1.08-1.90). The expression plasmids containing the pre-miR-149 sequence with C allele of rs2292832 transcribed higher amount of mature miR-149-5p/3p than these with T allele in the HeLa and SiHa cells. Therefore, the rs2292832 polymorphism might influence CC susceptibility through modulation of the procession of pre-miR-149 to mature miRNAs.
中文翻译:
microRNA中的遗传变异与子宫颈癌风险有关。
由于microRNA(miRNA)或其周围区域的遗传变异可以改变miRNA的加工,表达和最终生物学功能,因此我们调查了miRNA单核苷酸多态性(SNP)是否与宫颈癌(CC)易感性相关。在954例患者和1339例对照中对常见的miRNA SNP(即miR-146a rs2910164,miR-149 rs2292832,miR-196a2 rs11614913,miR-499 rs3746444,miR-605 rs2043556和miR-618 rs2682818)进行了基因分型。结果表明,与TT基因型相比,miR-149 rs2292832 TC / CC基因型与CC风险增加21%[比值比(OR)= 1.21,95%置信区间(CI)= 1.00-1.47]。在年龄≤48岁(OR = 1.55,95%CI = 1.16-2.06),有流产史(OR = 1.44,95%CI = 1.12-1.86)的受试者中,这种关联更为明显。绝经前状态(OR = 1.41,95%CI = 1.08-1.85)和临床II期CC患者(OR = 1.43,95%CI = 1.08-1.90)。在HeLa和SiHa细胞中,含有带有rs2292832的C等位基因的pre-miR-149序列的表达质粒所转录的成熟miR-149-5p / 3p数量比带有T等位基因的表达质粒高。因此,rs2292832多态性可能会通过调节pre-miR-149到成熟miRNA的进程来影响CC易感性。
更新日期:2019-11-01
中文翻译:
microRNA中的遗传变异与子宫颈癌风险有关。
由于microRNA(miRNA)或其周围区域的遗传变异可以改变miRNA的加工,表达和最终生物学功能,因此我们调查了miRNA单核苷酸多态性(SNP)是否与宫颈癌(CC)易感性相关。在954例患者和1339例对照中对常见的miRNA SNP(即miR-146a rs2910164,miR-149 rs2292832,miR-196a2 rs11614913,miR-499 rs3746444,miR-605 rs2043556和miR-618 rs2682818)进行了基因分型。结果表明,与TT基因型相比,miR-149 rs2292832 TC / CC基因型与CC风险增加21%[比值比(OR)= 1.21,95%置信区间(CI)= 1.00-1.47]。在年龄≤48岁(OR = 1.55,95%CI = 1.16-2.06),有流产史(OR = 1.44,95%CI = 1.12-1.86)的受试者中,这种关联更为明显。绝经前状态(OR = 1.41,95%CI = 1.08-1.85)和临床II期CC患者(OR = 1.43,95%CI = 1.08-1.90)。在HeLa和SiHa细胞中,含有带有rs2292832的C等位基因的pre-miR-149序列的表达质粒所转录的成熟miR-149-5p / 3p数量比带有T等位基因的表达质粒高。因此,rs2292832多态性可能会通过调节pre-miR-149到成熟miRNA的进程来影响CC易感性。