Monitoring of new phenethylamine designer drugs in oral fluid (OF) is a crucial aim in workplace testing and driving under the influence of drug programs. In this study a simple and very quick method for the quantification of 11 illicit drugs in OF, which gave negative results to immunoassay tests, is proposed. Sample treatment and extraction of analytes were simultaneously achieved by applying supramolecular solvents (SUPRAS) tool. Chromatographic separation and compounds quantification were carried out by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Efficacy of cleaning-up/extraction of this SUPRAS approach was fully confirmed by recovery and matrix effect results. The entire analytical procedure was validated following the international guidelines. The SUPRAS extraction coupled with LC-MS/MS resulted in powerful tool for the control of phenethylamines abuse, with rapid run time and minimal sample preparation. The use of this methodology could be easily extended to monitoring of other drugs of abuse.

中文翻译：

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基于己醇的超分子溶剂工具，通过LC-MS / MS测定口服液中的11种非法苯乙胺。

监测口服液（OF）中的新苯乙胺设计剂药物是在药物程序影响下进行工作场所测试和驾驶的关键目标。在这项研究中，提出了一种简单而快速的定量方法，用于定量OF中的11种违禁药物，该方法对免疫分析测试产生了负面影响。通过应用超分子溶剂（SUPRAS）工具，可以同时进行样品处理和分析物提取。通过液相色谱-串联质谱（LC-MS / MS）分析进行色谱分离和化合物定量。回收率和基质效应结果充分证实了该SUPRAS方法的清理/提取功效。整个分析过程均遵循国际准则进行了验证。SUPRAS萃取与LC-MS / MS结合使用，可提供功能强大的工具来控制苯乙胺的滥用，并且运行时间短且样品制备最少。这种方法的使用很容易扩展到监测其他滥用药物。