Co-inoculation of prion strains into the same host can result in interference, where replication of one strain hinders the ability of another strain to cause disease. The drowsy (DY) strain of hamster-adapted transmissible mink encephalopathy (TME) extends the incubation period or completely blocks the hyper (HY) strain of TME following intracerebral, intraperitoneal or sciatic nerve routes of inoculation. However, it is not known if the interfering effect of the DY TME agent is exclusive to the HY TME agent by these experimental routes of infection. To address this issue, we show that the DY TME agent can block hamster-adapted chronic wasting disease (HaCWD) and the 263K scrapie agent from causing disease following sciatic nerve inoculation. Additionally, per os inoculation of DY TME agent slightly extends the incubation period of per os superinfected HY TME agent. These studies suggest that prion strain interference can occur by a natural route of infection and may be a more generalized phenomenon of prion strains.

中文翻译：

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朊病毒干扰多个朊病毒分离株。

将朊病毒菌株共接种到同一宿主中会导致干扰，其中一种菌株的复制阻碍了另一种菌株引起疾病的能力。仓鼠适应性传染性水貂脑病 (TME) 的昏昏欲睡 (DY) 菌株延长了潜伏期或完全阻断了脑内、腹膜内或坐骨神经接种途径后 TME 的超 (HY) 菌株。然而，不知道 DY TME 剂的干扰作用是否是 HY TME 剂通过这些实验性感染途径所独有的。为了解决这个问题，我们表明 DY TME 试剂可以阻止仓鼠适应慢性消耗性疾病 (HaCWD) 和 263K 瘙痒病剂在坐骨神经接种后引起疾病。此外，DY TME 剂的经口接种稍微延长了经口重复感染的 HY TME 剂的潜伏期。这些研究表明朊病毒菌株干扰可以通过自然感染途径发生，并且可能是朊病毒菌株的一种更普遍的现象。