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The peculiar interaction between mammalian prion protein and RNA.
Prion ( IF 2.3 ) Pub Date : 2008-04-11 , DOI: 10.4161/pri.2.2.6988
Mariana P B Gomes 1 , Yraima Cordeiro , Jerson L Silva
Affiliation  

In the past decade, the interaction between prions and nucleic acids has garnered significant attention from the scientific community. for many years, the participation of RNA and/or DNA in prion pathology has been largely ruled out by the "protein-only" hypothesis, but this is now being reconsidered. Experimental data now indicate that nucleic acids (particularly RNA), besides being carriers of genetic information, function as important key components during development, physiological responsiveness and cellular signaling. This revelation has brought a new perspective to prion pathology. Here we discuss the role of RNA molecules in prion protein aggregation and the resulting cellular toxicity. We combine our most recent findings with existing literature to shed new light on this exciting field of research.

中文翻译:

哺乳动物朊病毒蛋白与 RNA 之间的特殊相互作用。

在过去的十年中,朊病毒与核酸之间的相互作用引起了科学界的极大关注。多年来,“仅蛋白质”假设在很大程度上排除了 RNA 和/或 DNA 参与朊病毒病理学,但现在正在重新考虑这一点。现在的实验数据表明,核酸(尤其是 RNA)除了作为遗传信息的载体外,还在发育、生理反应和细胞信号传导过程中作为重要的关键成分发挥作用。这一发现为朊病毒病理学带来了新的视角。在这里,我们讨论了 RNA 分子在朊病毒蛋白聚集中的作用以及由此产生的细胞毒性。我们将我们的最新发现与现有文献相结合,为这一激动人心的研究领域提供了新的思路。
更新日期:2019-11-01
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