KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta. They are members of the SLC6/NSS family, which groups membrane proteins that use Na(+), K(+), and Cl⁻ gradients for the coupled transport of amines and amino acids. The report of the atomic-resolution x-ray crystal structure of the eubacterium Aquifex aeolicus leucine transporter (AaLeuT) has contributed significantly to understanding of the structure-function relationship in NSS proteins. Transport by AaLeuT is Cl⁻ independent, whereas many neurotransmitter:sodium symporters like serotonin transporter (SERT), GABA transporter (GAT1), dopamine transporter, and norephinephrine transporter, among others, are strongly Cl⁻ dependent.

中文翻译：

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SLC6 / NSS家族成员KAAT1和CAATCH1具有弱的氯离子依赖性。

KAAT1和CAATCH1是从鳞翅目Manduca sexta的肠中克隆的氨基酸转运蛋白。它们是SLC6 / NSS家族的成员，该家族对使用Na（+），K（+）和Cl +梯度进行胺和氨基酸的偶联运输的膜蛋白进行分组。真细菌Aquifex aeolicus亮氨酸转运蛋白（AaLeuT）的原子分辨率x射线晶体结构的报告对理解NSS蛋白中的结构-功能关系做出了重要贡献。AaLeuT的转运是不依赖Cl⁻的，而许多神经递质：钠转运蛋白，如血清素转运蛋白（SERT），GABA转运蛋白（GAT1），多巴胺转运蛋白和去甲肾上腺素转运蛋白等，都高度依赖Cl⁻。