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Apoptosis in human endometrium and endometriosis.
Human Reproduction Update ( IF 13.3 ) Pub Date : 2004-03-10 , DOI: 10.1093/humupd/dmh007
T Harada 1 , A Kaponis , T Iwabe , F Taniguchi , G Makrydimas , N Sofikitis , M Paschopoulos , E Paraskevaidis , N Terakawa
Affiliation  

Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that apoptosis helps to maintain cellular homeostasis during the menstrual cycle by eliminating senescent cells from the functional layer of the uterine endometrium during the late secretory and menstrual phase of the cycle. The BCL-2 family and Fas/FasL system have been extensively studied in human endometrium and endometriotic tissues. Eutopic endometrium from women with endometriosis reportedly has some fundamental differences compared with normal endometrium of women without endometriosis. The differences could contribute to the survival of regurgitating endometrial cells into the peritoneal cavity and the development of endometriosis. One mechanism that recently gained a lot of interest is the finding that apoptosis appeared in eutopic and ectopic endometrium of patients with endometriosis. This study is a current review of the literature focused on the physiological role of apoptosis in normal endometrium and the alterations in regulation of apoptosis in eutopic and ectopic endometrium from women with endometriosis. Similarities in characteristics of endometriosis at a molecular level with gynaecological tumours are also discussed. Finally, the role of apoptosis in the treatment of endometriosis is reviewed to link the basic research findings into clinical applications.

中文翻译:

人子宫内膜细胞凋亡和子宫内膜异位症。

凋亡在维持组织稳态中起着关键作用,并代表消除多余或功能异常细胞的正常功能。积累的证据表明,凋亡可通过在周期的晚期分泌和月经阶段从子宫内膜的功能层清除衰老细胞来帮助维持月经周期的细胞稳态。BCL-2家族和Fas / FasL系统已在人体子宫内膜和子宫内膜异位组织中进行了广泛研究。据报道,子宫内膜异位症女性的子宫内膜异位与非子宫内膜异位症女性的正常子宫内膜有一些根本差异。这些差异可能有助于将子宫内膜细胞反流到腹膜腔中并存活并发展子宫内膜异位。最近引起广泛关注的一种机制是发现凋亡在子宫内膜异位症患者的对位和异位子宫内膜中出现。这项研究是目前的文献综述,侧重于子宫内膜异位症患者正常子宫内膜中的凋亡的生理作用以及对位和异位子宫内膜中细胞凋亡的调控变化。还讨论了子宫内膜异位症在分子水平上与妇科肿瘤的相似性。最后,综述了凋亡在子宫内膜异位症治疗中的作用,以将基础研究结果与临床应用联系起来。这项研究是目前的文献综述,侧重于子宫内膜异位症患者正常子宫内膜中的凋亡的生理作用以及对位和异位子宫内膜中细胞凋亡的调控变化。还讨论了子宫内膜异位症在分子水平上与妇科肿瘤的相似性。最后,综述了凋亡在子宫内膜异位症治疗中的作用,以将基础研究结果与临床应用联系起来。这项研究是目前的文献综述,侧重于子宫内膜异位症患者正常子宫内膜中的凋亡的生理作用以及对位和异位子宫内膜中细胞凋亡的调控变化。还讨论了子宫内膜异位症在分子水平上与妇科肿瘤的相似性。最后,综述了凋亡在子宫内膜异位症治疗中的作用,以将基础研究结果与临床应用联系起来。
更新日期:2019-11-01
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